Showing 881-890 of 21415 results for "".
- HER2+ Syngeneic Murine Models for Brain Metastasis and CNS Drug Testinghttps://reachmd.com/news/her2-syngeneic-murine-models-for-brain-metastasis-and-cns-drug-testing/2486329/Investigators report engineering immunocompetent, syngeneic murine mammary carcinoma models to express human HER2 (wild-type and the exon 20 insertion HER2YVMA) and to track spontaneous brain metastasis using a GFP tag. Using both 4T1 (BALB/c background) and EO771 (C57BL/6 background) backb
- Navigating the New COPD Era: Biologics, Guidelines, and Clinical Challengeshttps://reachmd.com/news/navigating-the-new-copd-era-biologics-guidelines-and-clinical-challenges/2484584/Dupilumab has emerged as a practice-changing option for patients with eosinophilic COPD, offering targeted anti–type 2 pathway therapy for those who continue to have frequent exacerbations despite optimized inhaled regimens; this development expands treatment choices for a high-risk
- A Paradigm Shift: Non-Opioid Alternatives in Pain Managementhttps://reachmd.com/news/a-paradigm-shift-non-opioid-alternatives-in-pain-management/2483366/The current landscape of pain management is fraught with challenges. Opioids, while effective for acute and some types of severe pain, carry risks of misuse, addiction, and overdose. These realities have intensified interest in non-opioid approaches that aim to relieve pain while minimizing
- Oral GLP-1 Hits Phase 3 Trial Targets; Regulatory Submissions Cominghttps://reachmd.com/news/oral-glp-1-hits-phase-3-trial-targets-regulatory-submissions-coming/2483149/Eli Lilly and Company announced positive topline results from its Phase 3 ATTAIN-2 trial, showing that its investigational oral GLP-1 receptor agonist, orforglipron, achieved significant weight loss and improved cardiometabolic outcomes in adults with obesity or overweight status and type 2 diabe
- Biologic Therapies Redefine COPD Treatment Paradigmshttps://reachmd.com/news/biologic-therapies-redefine-copd-treatment-paradigms/2475760/Biologic therapies are redefining treatment paradigms in COPD, with the first FDA-approved agent targeting eosinophilic disease—mepolizumab—emphasizing the specific role of eosinophils, while dupilumab offers promise for broader type 2 inflammatory COPD by also targeting other infla
- Dendritic Cells and the Future of Food Allergy Preventionhttps://reachmd.com/news/dendritic-cells-unraveling-mechanisms-in-food-allergy-prevention/2474218/In the evolving landscape of food allergy research, one cell type is taking center stage for its gatekeeping role in immune education: the dendritic cell. Long regarded as sentinels of the immune system, dendritic cells are now drawing focused attention for their p
- New Blood Test for Rapid Stroke Diagnosishttps://reachmd.com/news/new-blood-test-for-rapid-stroke-diagnosis/2471076/What's New A new blood test has the potential to swiftly distinguish between brain bleeds and clot-caused strokes, expediting crucial early treatments. Significance Timely identification of stroke type can significantly impact treatment outcomes, reducing brain damage and
- Study Highlights Widespread Childhood Adversity: 80.5 Percent of Adolescents Affectedhttps://reachmd.com/news/study-highlights-widespread-childhood-adversity-805-percent-of-adolescents-affected/2468746/Adverse childhood experiences (ACEs) are highly prevalent among U.S. adolescents, with 80.5 percent reporting at least one ACE, according to a new study published in Pediatrics. This study provides critical insights into the types and frequency of ACEs and underscores disparities across
- Study Compares Effectiveness of Cetuximab and Durvalumab in Treating Head and Neck Cancershttps://reachmd.com/news/study-compares-effectiveness-of-cetuximab-and-durvalumab-in-treating-head-and-neck-cancers/2468718/A new study has provided critical insights into the treatment options for head and neck cancer patients who are unable to tolerate cisplatin, establishing cetuximab as the preferred alternative in this population. Head and neck cancers are the seventh most common cancer type globally, ofte
- Concussions in High School Football Players Linked to Slowed Brain Activityhttps://reachmd.com/news/concussions-in-high-school-football-players-linked-to-slowed-brain-activity/2468683/New research has uncovered a significant impact of concussions on an often-overlooked aspect of brain function in high school football players. The study focused on how concussions affect "aperiodic" brain activity—a type of signaling once dismissed as background noise in brain imaging. These fin