Showing 4941-4950 of 21485 results for "".
- CXCR4 and PD-1 Blockade in PDAC Modelshttps://reachmd.com/news/cxcr4-and-pd-1-blockade-in-pdac-models/2488216/Key Takeaways In human PDAC tumor tissue and matched blood samples, T-cells showed a CD4-skewed pattern; in three-dimensional and patient-derived spheroid systems, infiltrating T-cells showed checkpoint upregulation within a fibroblast-rich microenvironment. Tumor-as
- COPD Continuity of Care Linked to Fewer Hospitalizationshttps://reachmd.com/news/copd-continuity-of-care-linked-to-fewer-hospitalizations/2488193/Key Takeaways Among older adults with newly diagnosed COPD in South Korea’s national insurance cohort, lower outpatient continuity was associated with higher COPD-related hospitalization and all-cause mortality. Risk increased stepwise as continuity worsened from hig
- Brain MRI Findings in CPP Cluster in Younger Childrenhttps://reachmd.com/news/brain-mri-findings-in-cpp-cluster-in-younger-children/2488200/Key Takeaways In a retrospective MRI cohort of 1,087 children with CPP or EFP at a single Chinese center, intracranial lesions were detected in 14.5% of girls and 19.6% of boys. All 26 pathogenic lesions were identified in children with CPP, and none were found in ch
- Night-Before Dexmedetomidine Cut Delirium After Arthroplastyhttps://reachmd.com/news/night-before-dexmedetomidine-cut-delirium-after-arthroplasty/2488198/Key Takeaways Older adults undergoing total hip or knee arthroplasty under general anesthesia had lower 3-day postoperative delirium with night-before intranasal dexmedetomidine than with placebo, 10.3% versus 20.7%. Subjective sleep quality improved with intranasal
- COVID-19 Linked to Broad Long-Term Morbidity in Englandhttps://reachmd.com/news/covid-19-linked-to-broad-long-term-morbidity-in-england/2488195/Key Takeaways In adults in England, COVID-19 was linked to higher incidence of most assessed longer-term health outcomes across pre-vaccination, vaccinated, and electively unvaccinated settings. Post-COVID hazards rose early after diagnosis and remained elevated well
- Real-World Adult-Onset Still’s Disease Treatment Patternshttps://reachmd.com/news/real-world-adult-onset-stills-disease-treatment-patterns/2488184/Key Takeaways In Italian real-world care for active AOSD, 97.7% of patients received GCs, 58.8% received csDMARDs, and 43.3% received bDMARDs. Biologic use was led by IL-1 inhibition, while IL-6 and tumor necrosis factor inhibition were used much less often. Most pat
- Knee Angle Alters Quadriceps Fatigue and Critical Torquehttps://reachmd.com/news/knee-angle-quadriceps-fatigue-critical-torque/2488187/Key Takeaways In 13 physically active adults performing repeated maximal isometric knee extensions, total impulse was highest at the individualized optimal knee angle and was lower at −30°, +15°, and +30°. W′ was lower at every nonoptimal knee angle, falling by about
- Hidradenitis Suppurativa Linked to Higher Cardiovascular Risk: Meta-Analysishttps://reachmd.com/news/hidradenitis-suppurativa-linked-to-higher-cardiovascular-risk-meta-analysis/2488190/Hidradenitis suppurativa (HS) was associated with increased risk of multiple cardiovascular outcomes in a systematic review and meta-analysis encompassing 373,689 individuals with the chronic inflammatory skin disease. Cardiovascular Comorbidities and Hidradenitis Suppurativa
- Retinal AI Benchmark Finds Compact Pretrained Models Outperformhttps://reachmd.com/news/retinal-ai-benchmark-finds-compact-pretrained-models-outperform/2488165/Key Takeaways Across retinal imaging classification tasks in OCT and color fundus photography, pretrained models delivered better accuracy on every task than scratch-trained counterparts, and each comparison was statistically significant. Compact models in the roughl
- Weekly Oral HIV Maintenance Therapy Matches Daily B/F/TAFhttps://reachmd.com/news/weekly-oral-hiv-maintenance-therapy-matches-daily-bftaf/2488167/Key Takeaways Adults with HIV-1 already suppressed on daily B/F/TAF had similar week-48 viral suppression after switching to once-weekly oral ISL/LEN or continuing daily therapy. No participants assigned to weekly ISL/LEN and 0.3% of those continuing daily B/F/TAF ha