Showing 3941-3950 of 21451 results for "".
- Spot Sepsis Study Reports Improved Referral Prediction In Febrile Childrenhttps://reachmd.com/news/spot-sepsis-study-reports-improved-referral-prediction-in-febrile-children/2486970/Key Takeaways Models combining simple clinical signs with pulse oximetry or sTREM1 were reported to recognize more high-risk children than current WHO danger signs. The newer approaches were projected to lower referral burden substantially compared wit
- Secukinumab Falls Short in Phase III SELUNE Trialhttps://reachmd.com/news/secukinumab-phase-iii-selune-lupus-nephritis/2486924/Key Takeaways In SELUNE, complete renal response at week 52 was lower with secukinumab than with placebo in lupus nephritis. Adverse event rates were broadly similar, no new or unexpected safety signals emerged overall. In the
- Novel hs-cTnT Assay Doubles Early Myocardial Infarction Rule-Outhttps://reachmd.com/news/novel-hs-ctnt-assay-doubles-early-myocardial-infarction-rule-out/2486844/Key Takeaways The study-derived threshold below 13 ng/L was associated with more low-risk classification at presentation than the fifth-generation hs-cTnT approach. In external validation, 782 of 1721 patients, or 45.4%, were below 13 ng/L, with NPV 99
- Enzalutamide Improves Overall Survival in Biochemical Recurrencehttps://reachmd.com/news/enzalutamide-improves-overall-survival-in-biochemical-recurrence/2486842/Key Takeaways Combination therapy was associated with longer overall survival than leuprolide alone in the final analysis. Enzalutamide monotherapy was not significantly different from leuprolide alone for overall survival. Descriptive updates
- CHMP Issues Positive Opinion for Redemplo in Adult FCShttps://reachmd.com/news/chmp-issues-positive-opinion-for-redemplo-in-adult-fcs/2486870/Key Takeaways The CHMP adopted a positive opinion recommending REDEMPLO for adults with familial chylomicronemia syndrome as an adjunct to diet to reduce triglyceride levels. In PALISADE, lower triglycerides and fewer acute pancreatitis cases were repo
- Tucidinostat Plus R-CHOP Improves Event-Free Survival in DEL DLBCLhttps://reachmd.com/news/tucidinostat-plus-r-chop-improves-event-free-survival-in-del-dlbcl/2486810/Key Takeaways Event-free survival was better with tucidinostat plus R-CHOP than with placebo plus R-CHOP. Complete response was observed more often with the tucidinostat-containing regimen. Toxicity was higher with tucidinostat and was general
- Gut Microbiome Patterns Linked to IBS-D Response to Rifaximin, Diethttps://reachmd.com/news/gut-microbiome-patterns-linked-to-ibs-d-response-to-rifaximin-diet/2486812/Key Takeaways Five-week decreases in abdominal pain and bloating were comparable after rifaximin and low FODMAP diet counseling. Baseline microbiome features differed among low FODMAP responders, rifaximin responders, and patients who did not respond t
- Secukinumab In SELUNE: Phase III Lupus Nephritis Readouthttps://reachmd.com/news/secukinumab-in-selune-phase-iii-lupus-nephritis-readout/2486777/Key Takeaways Complete renal response at week 52 was lower with secukinumab than with placebo. No differences were seen across secondary endpoints, and treatment-emergent adverse events were similar between groups. A planned futility analysis
- AI Immune Profiling on Histopathology Slides in Rectal Cancerhttps://reachmd.com/news/ai-immune-profiling-on-histopathology-slides-in-rectal-cancer/2486667/Key Takeaways TIL positivity was associated with longer disease-free and overall survival, while TAM positivity was associated with shorter disease-free survival in the main cohort. Similar directional patterns were described across the additional coho
- Tecovirimat Fails to Improve Key Mpox Outcomes in Phase 3 Trialhttps://reachmd.com/news/tecovirimat-fails-to-improve-key-mpox-outcomes-in-phase-3-trial/2486673/Key Takeaways Tecovirimat was reported as not outperforming placebo on key mpox outcomes in this randomized phase 3 study. The trial enrolled 412 participants, used 2 to 1 randomization, and compared 14 days of tecovirimat with placebo across multiple