"Patient engagement" is a broadly encompassing term that takes on various forms depending on the point of view, from the physician's drive toward better treatment compliance and health literacy to the patient's stance on being heard and understood through the care continuum. How can the medical profession assess, measure, and improve patient engagement indexes from both points of view? Host Alicia Sutton welcomes Pete Sheldon, president of Opus Science, LLC based in Annapolis, MD, to describe strategies employed locally and nationwide to enhance patient engagement.