Obscure gastrointesinal bleeding can pose investigational challenges. What are the potential causes of obscure GI bleeding? After initial negative upper endoscopy and colonoscopy tests are performed, what new technologies can help physicians more effectively detect small bowel abnormalities? Dr. Jonathan Leighton, professor of medicine and chair of the division of gastroenterology at the Mayo Clinic in Arizona, and Dr. Moshe Rubin, director of gastroenterology and program director of the GI fellowship training program at New York Hospital Queens Medical Center and the Weill-Cornell Medical College in New York, discuss the roles of small bowel capsule endoscopy, balloon-assisted enteroscopy, spiral enteroscopy, and CT enterography in evaluating patients with obscure GI bleeding. Dr. Jay Goldstein hosts.