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William V. Tamborlane, MD
William V. Tamborlane, MD

    Dr. William V. Tamborlane, Jr., is professor and chief of pediatric endocrinology and diabetes at Yale University School of Medicine in New Haven, Connecticut. He is a graduate of Georgetown University School of Medicine in Washington, DC, where he completed his residency in pediatrics, before going to Yale as a post-doctoral fellow in endocrinology and metabolism in both pediatrics and medicine.

    Dr. Tamborlane has devoted his academic career to patient-oriented research in disease pathophysiology and therapeutics. His scientific accomplishments over the past 30 years have established his international reputation as one of the most highly regarded clinical scientists in childhood diabetes and related disorders. Major achievements have included pioneering studies in the development of insulin pump therapy, investigations of diabetes-induced defects in counter-regulatory hormone responses to hypoglycemia, and demonstration of the role of insulin resistance in pediatric metabolic disorders, including obesity and type 2 diabetes. Current research effort is directed at translating recent advances in insulin pump and glucose sensor technology into improved treatments of children and adolescents with type 1 diabetes with the ultimate objective of developing a closed-loop artificial pancreas.

    He has published more than 460 original articles, book chapters and reviews in the area of diabetes and metabolic disorders and was editor-in-chief of the Yale Guide to Children's Nutrition, published by Yale University press in 1997. He is the recipient of many awards and honors and is frequently listed in publications of distinction, including American Men and Women of Science, Who's Who in America, The Best Doctors in America, America's Top Doctorsand America's Top Pediatricians. In 2006, he was awarded the Mary Tyler Moore and S. Robert Levine Award for Excellence in Clinical Research in Type 1 Diabetes by the Juvenile Diabetes Research Foundation.

    Dr. Tamborlane has extensive experience in the design and participation in National Institutes of Health-sponsored multi-center studies.  He has been primary investigator of Yale's Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Center for more than 25 years, primary investigator of Yale's Center in the Pediatric Pharmacology Research Unit Network (PPRU) and a co-investigator of the Treatment Options for Type 2 Diabetes in Adolescents and Youth (the TODAY study). He was steering committee chair of the NICHD-sponsored Diabetes Research in Children Network (DirecNet), which has examined the efficacy of new continuous glucose monitoring systems in management of youth with type 1 diabetes and is currently co-chair of the JDRF CGM Study Group. He is a former member of the National Board of Directors of the American Diabetes Association and is a current member of the Clinical Advisory Board of the JDRF and Diabetes Advisory Boards of several companies.

    Dr. Tamborlane also has extensive experience working with the Food and Drug Administration and with industry. He served on the FDA Diabetes and Metabolism Advisory Board, was a featured speaker at the FDA/National Institutes of Health symposium that examined pathways to approval of new drugs and devices in diabetes, and has been a consultant for industry in pre-and post- Investigational New Drug meetings with FDA staff. He has also served as a consultant in the development of pivotal clinical trials of new diabetes drugs and new devices for FDA approval, been the Yale primary investigator for several of the resulting Phase 2 and 3 trials, and is a member of a number of diabetes advisory boards of pharmaceutical and device companies.

    As program director of the Yale Children's General Clinic Research Center, he managed the clinical research resources for studies in childhood diseases for 17 years and is now the deputy director of the Yale Center for Clinical Investigation. As chief of pediatric endocrinology, he has built a small section into a national center of excellence in research, training and clinical care in pediatric endocrinology. He leads a multidisciplinary team of physicians, diabetes nurse educators, dieticians and social workers that care for more than 1000 children, adolescents and young adults with diabetes.

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