Showing 9691-9700 of 20328 results for "".
- Animal Models for Swine Influenza: Model Roles, Limits, and Surveillance Implicationshttps://reachmd.com/news/animal-models-for-swine-influenza-model-roles-limits-and-surveillance-implications/2486032/A recent review of swine influenza animal models describes how experimental readouts can shift depending on whether studies are conducted in mice, ferrets, guinea pigs, pigs, or non-human primate
- Sotyktu Gets FDA Nod as First TYK2 Inhibitor for Psoriatic Arthritishttps://reachmd.com/news/sotyktu-gains-fda-approval-as-first-tyk2-inhibitor-for-psoriatic-arthritis/2486046/The US Food and Drug Administration (FDA) has approved deucravacitinib (Sotyktu; Bristol Myers Squibb) for the treatment of adults with active psoriatic arthritis (PsA), representing the first oral therapy in its class approved for the treatment of the condition, a
- IL‑2–Armored FLT3 CAR‑γδT Cells: Preclinical Efficacy and Translational Signalshttps://reachmd.com/news/il2armored-flt3-cart-cells-preclinical-efficacy-and-translational-signals/2486036/Investigators report a preclinical evaluation of FLT3-targeted CAR-γδT cells “armored” to co-express IL-2 or IL-7 in acute myeloid leukemia (AML) models. The study describes three engineered prod
- Comparative Outcomes of Fluticasone‑Based vs Budesonide Dual Inhalers in COPDhttps://reachmd.com/news/comparative-outcomes-of-fluticasonebased-vs-budesonide-dual-inhalers-in-copd/2486037/Investigators reported comparative outcomes among US adults aged 40 years or older with chronic obstructive pulmonary disease (COPD) who initiated one of three inhaled corticosteroid–long-acting β-agonist (ICS–LABA) single-inhaler products in
- INTEGUMENT-OLE Data Show Sustained Efficacy of Roflumilast in Early Childhood ADhttps://reachmd.com/news/integument-ole-data-show-sustained-efficacy-of-roflumilast-in-early-childhood-ad/2486045/The 56-week phase 3 open-label extension for the INTEGUMENT trial (INTEGUMETN-OLE) indicated once-daily roflumilast cream 0.05% maintained efficacy and demonstrated favorable long-term safety in children aged 2 to 5 years with mild-to-moderate atopic dermatitis (AD
- Integrated MALDI‑TOF MS and WGS in a Prolonged ICU Pseudomonas Outbreakhttps://reachmd.com/news/integrated-malditof-ms-and-wgs-in-a-prolonged-icu-pseudomonas-outbreak/2486016/In a prolonged intensive care unit (ICU) outbreak investigation of Pseudomonas aeruginosa, authors report using an integrated laboratory approach that combined phenotypic antimicrobial testing,
- Intranasal Dexmedetomidine Combined with Oral Chloral Hydrate or Midazolam: RCT Resultshttps://reachmd.com/news/intranasal-dexmedetomidine-combined-with-oral-chloral-hydrate-or-midazolam-rct-results/2486004/In a randomized head-to-head outpatient study of pediatric procedural sedation regimens, Li and colleagues evaluated intranasal dexmedetomidine paired with either ora
- AMPAR PET Imaging Links Ketamine to Rapid Antidepressant Responsehttps://reachmd.com/news/ampar-pet-imaging-links-ketamine-to-rapid-antidepressant-response/2486011/Investigators used PET imaging to visualize cell-surface AMPA receptor (AMPAR) dynamics in people with treatment-resistant depression in relation to ketamine’s antidepressant effects, describing region-specific receptor changes associated with symptom improvement.
- Gut Microbiome and Checkpoint Immunotherapy: Reporting Recent Synthesishttps://reachmd.com/news/gut-microbiome-and-checkpoint-immunotherapy-reporting-recent-synthesis/2485990/An integrated review examined how gut microbial communities relate to variable outcomes with PD-1/PD-L1 checkpoi
- 4‑Chlorothienopyridine Caps Yield Potent, Selective HDAC Inhibitors — Preclinical Reporthttps://reachmd.com/news/4chlorothienopyridine-caps-yield-potent-selective-hdac-inhibitors-preclinical-report/2486007/Investigators report a series of hydroxamic-acid HDAC inhibitors built around substituted 4-chlorothieno[2,3-b]pyridine cap groups, spanning series 6a–c and 7a–c (aliphatic linkers) and 9a–c (cinnamic linkers). Each combines a cap, spacer, and hydroxamic acid zinc-binding motif in the final