Showing 1251-1260 of 20877 results for "".
- Intranasal Dexmedetomidine Combined with Oral Chloral Hydrate or Midazolam: RCT Resultshttps://reachmd.com/news/intranasal-dexmedetomidine-combined-with-oral-chloral-hydrate-or-midazolam-rct-results/2486004/In a randomized head-to-head outpatient study of pediatric procedural sedation regimens, Li and colleagues evaluated intranasal dexmedetomidine paired with either ora
- AMPAR PET Imaging Links Ketamine to Rapid Antidepressant Responsehttps://reachmd.com/news/ampar-pet-imaging-links-ketamine-to-rapid-antidepressant-response/2486011/Investigators used PET imaging to visualize cell-surface AMPA receptor (AMPAR) dynamics in people with treatment-resistant depression in relation to ketamine’s antidepressant effects, describing region-specific receptor changes associated with symptom improvement.
- Gut Microbiome and Checkpoint Immunotherapy: Reporting Recent Synthesishttps://reachmd.com/news/gut-microbiome-and-checkpoint-immunotherapy-reporting-recent-synthesis/2485990/An integrated review examined how gut microbial communities relate to variable outcomes with PD-1/PD-L1 checkpoi
- 4‑Chlorothienopyridine Caps Yield Potent, Selective HDAC Inhibitors — Preclinical Reporthttps://reachmd.com/news/4chlorothienopyridine-caps-yield-potent-selective-hdac-inhibitors-preclinical-report/2486007/Investigators report a series of hydroxamic-acid HDAC inhibitors built around substituted 4-chlorothieno[2,3-b]pyridine cap groups, spanning series 6a–c and 7a–c (aliphatic linkers) and 9a–c (cinnamic linkers). Each combines a cap, spacer, and hydroxamic acid zinc-binding motif in the final
- EEG Time‑Frequency Images Predict SSRI and rTMS Responsehttps://reachmd.com/news/eeg-timefrequency-images-predict-ssri-and-rtms-response/2485996/Authors describe a pretreatment resting-EEG deep-learning pipeline that converts baseline recordings into time–frequency EEG images and evaluates models that classify SSRI and rTMS responder versus non-responder status. Performance is presented at both the image lev
- Human hIEC Model Reports High Accuracy for Detecting Drug-Induced Intestinal Barrier Damagehttps://reachmd.com/news/human-hiec-model-reports-high-accuracy-for-detecting-drug-induced-intestinal-barrier-damage/2485995/The report describes a stem-cell–derived hIEC model designed to detect drug-induced intestinal barrier impairment by recreating key aspects of
- Examining IV Acetaminophen as Adjunct to Titrated IV Morphinehttps://reachmd.com/news/acetaminophen-titrated-morphine-adjunct/2485961/A multicenter trial evaluated whether IV morphine plus placebo was noninferior to IV morphine plus IV acetaminophen for earl
- Gut-Restricted LXR Agonist Reduces Liver Injury After Short Bowel Resectionhttps://reachmd.com/news/gut-restricted-lxr-agonist-reduces-liver-injury-after-short-bowel-resection/2485974/Radical small bowel resection can be lifesaving, but it is also associated with serious downstream morbidity, including intestinal failure–associated liver disease (IFALD) in the setting of short bowel syndrome. Against that clinical backdrop,
- CAR‑Astrocyte Therapy: Single‑Injection Amyloid Clearance Reported in Micehttps://reachmd.com/news/carastrocyte-therapy-singleinjection-amyloid-clearance-reported-in-mice/2485966/A report on CAR-astrocytes describes a preclinical approach in a mouse model of amyloid pathology. Investigators report peripheral, noninvasi
- Study Reports Improved Tolerability with Biomimetic Exosome Retinalhttps://reachmd.com/news/study-reports-improved-tolerability-with-biomimetic-exosome-retinal/2485852/A novel retinal formulation delivered via a biomimetic exosome platform was associated with significant clinical improvements in photodamaged skin without reported irritation, according to a 12-week study published in the Journal of Cosmetic Dermatology. In the single-center study