Showing 1031-1040 of 1560 results for "".
- Pre-Existing COPD and Its Association with Checkpoint Inhibitor Pneumonitis in NSCLChttps://reachmd.com/news/pre-existing-copd-and-its-association-with-checkpoint-inhibitor-pneumonitis-in-nsclc/2474352/As immune checkpoint inhibitors (ICIs) cement their role in the management of non-small cell lung cancer (NSCLC), clinicians are encountering new layers of complexity in patient care—particularly for individuals with pre-existing chronic obstructive pulmonary disea
- Alemtuzumab Highly Effective in CTCL Without Papular History: Analysishttps://reachmd.com/news/study-alemtuzumab-highly-effective-in-ctcl-without-papular-history/2474209/A new analysis suggests the absence of papules, plaques, and tumors (PPT) in cutaneous T-cell lymphoma (CTCL) may predict favorable clinical outcomes with low dose alemtuzumab (LDA) therapy. In a retrospective cohort study
- The Role of 3D Gene Architecture in Glioblastomahttps://reachmd.com/news/the-role-of-3d-gene-architecture-in-glioblastoma/2474273/This article investigates the association between the three-dimensional folding of DNA within brain cells and glioblastoma. Leveraging preclinical research from Weill Cornell Medicine, it examines the impact of disruptions in 3D gene hubs on cellular functions.
- Lipid Metabolism and Immune System Aging: Exploring the Role of Key Enzymeshttps://reachmd.com/news/lipid-metabolism-and-immune-system-aging-exploring-the-role-of-key-enzymes/2474233/Emerging research reveals that the enzyme ELOVL2, crucial in lipid metabolism, is linked to reduced immune cell production in older adults, heightening infection susceptibility. This research is vital for fields such as Allergy, Asthma, and Immu
- Lung Cancer: Investigating Protein Agrin’s Role in Treatment Resistancehttps://reachmd.com/news/lung-cancer-investigating-protein-agrins-role-in-treatment-resistance/2474107/A study at Roswell Park Comprehensive Cancer Center reveals that protein agrin may significantly influence treatment resistance and relapse in lung cancer. By promoting tumor cell growth, fostering an immunosuppressive microenvironment, and activating pivotal signaling path
- GSK3β Activation and Drug Resistance in BRAF Mutant Melanomahttps://reachmd.com/news/gsk3-activation-and-drug-resistance-in-braf-mutant-melanoma/2474108/A publication in Oncotarget highlights the pivotal role of GSK3β activation in melanoma cells, identifying it as a factor contributing to decreased sensitivity to Raf inhibitors. This underscores a fundamental challenge in overcoming drug resistance in
- The Role of Macrophage Reprogramming in Cancer Immunotherapyhttps://reachmd.com/news/the-role-of-macrophage-reprogramming-in-cancer-immunotherapy/2474085/Macrophage reprogramming is emerging as a groundbreaking strategy in oncology. Researchers have discovered that these adaptable immune cells can either promote tumor propagation or combat cancer and that directing them towards an antitumor stance by modulating immu
- Unraveling TREM2’s Role in Cognitive Decline and Neuroinflammation in Parkinson’s Diseasehttps://reachmd.com/news/unraveling-trem2s-role-in-cognitive-decline-and-neuroinflammation-in-parkinsons-disease/2474002/A growing body of research is zeroing in on a key molecular player in Parkinson’s disease—TREM2, or Triggering Receptor Expressed on Myeloid cells 2—as a critical modulator of neuroinflammation and cognitive deterioration. Once primarily associated with Alzheimer’s
- Study Links Psoriasis Gene Regulation to Spatial Genome Changeshttps://reachmd.com/news/study-links-psoriasis-gene-regulation-to-spatial-genome-changes/2474007/Results from a new study in the Journal of Investigative Dermatology showed how changes in the 3D chromatin architecture of CD4+ T cells contribute to immune dysregulation in psoriasis. "In this study, the 3D genomic
- Female Hormones: Mediators of Immune-Derived Pain Suppressionhttps://reachmd.com/news/female-hormones-mediators-of-immune-derived-pain-suppression/2473954/Innovative studies at UC San Francisco have uncovered an intriguing mechanism: female hormones stimulate immune cells in the meninges surrounding the spinal cord, leading to the release of enkephalin, a natural opioid. This discovery enhances our understanding of t