New mothers should be bonding with their newborns instead of worrying about postpartum depression (PPD), which could take away from this exciting time in patients' lives. And it’s estimated that up to one in seven mothers experience PPD. Here you can read about a new therapy that could benefit patients with PPD.
Postpartum depression (PPD) is a common yet often misunderstood mental health disorder that affects new mothers after childbirth. It is estimated that up to one in seven mothers experience postpartum depression, which can have significant negative effects on their own health and well-being, as well as their ability to care for and bond with their newborn. Despite the prevalence of this disorder, treatment options have been limited, until now. Zuranolone, a new medication recently approved by the FDA, offers hope for mothers struggling with postpartum depression.
Postpartum depression is a mood disorder that can occur after childbirth and affects around 15 percent of new mothers. PPD may begin within days of delivery or even several weeks or months afterward and can last for several months or longer if left untreated. Symptoms may include loss of interest in activities, sleep disturbances, feelings of sadness or hopelessness, difficulty bonding with the baby, and even thoughts of self-harm or suicide. Despite the high prevalence of PPD, many mothers are hesitant to seek treatment due to stigma or concerns about the safety of medications while breastfeeding.
Zuranolone, also known as SAGE-217, is a neuroactive steroid that works by increasing levels of a neurotransmitter called GABA, which has been shown to play a role in mood regulation. This medication is taken orally with a once-daily regimen for 14 days and has been demonstrated to improve depressive symptoms in PPD patients. In clinical trials, zuranolone was shown to provide significant improvements in depression scores within days of starting treatment with sustained benefits lasting for up to a month after discontinuation. This rapid onset of action may be especially beneficial for new mothers who may be reluctant to take medications for an extended period of time.
Regarding its safety profile, this medication has been shown to have minimal side effects with the most common adverse events reported being sedation, dizziness, and dry mouth. Additionally, because neuroactive steroids, like zuranolone, are broken down in the liver rather than the kidneys, there is a lower risk of drug interactions or adverse effects on renal function, which is particularly important for patients who may be taking multiple medications postpartum.
The approval of zuranolone for PPD marks an important milestone in the treatment of this common and often debilitating condition. The drug’s rapid onset of action, easy oral dosing, and favorable safety profile make it an attractive option for healthcare providers treating patients with PPD. Zuranolone is also an important step forward in reducing the stigma surrounding mental health disorders, particularly, in new mothers who may feel ashamed or embarrassed to seek treatment for their symptoms.