Mechanism of Disease: Immunoglobulin A Nephropathy

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Mechanism of Disease: Immunoglobulin A Nephropathy



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    Take a deep dive into the complex, multi-hit pathogenesis of immunoglobulin A nephropathy.

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    • Overview

      The four-hit hypothesis is the prevailing framework of immunoglobin A nephrology (IgAN) pathogenesis.1-4 In fact, these four hits drive disease pathogenesis and progression, ultimately causing kidney injury through the deposition of immune complexes in the mesangium.3,4 Learn more about the four hits of IgAN and how this chronic autoimmune disease can impact patients in this brief video.


      1. Wyatt RJ, Julian BA. IgA nephropathy. N Engl J Med. 2013;368(25):2402-2414.
      2. Mestecky J, Raska M, Julian BA, et al. IgA nephropathy: molecular mechanisms of the disease. Annu Rev Pathol. 2013;8:217-240.
      3. Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol. 2011;22(10):1795-1803.
      4. Suzuki H. Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis. Clin Exp Nephrol. 2019;23:26-31.

      February 2024 US.UNB.X.24.00004

    Schedule23 Apr 2024