Millions of Americans have esophageal disorders, ranging in severity from gastroesophogeal reflux (or GERD) to eosinophilic esophagitis to esophageal cancer. A diet rich in acidic or fatty foods can be to blame, but there are a number of other factors that may contribute to the development of GI disorders. When can physicians rely on empirical use of proton pump inhibitors, and when is endoscopy warranted? Dr. Gary Falk, professor of medicine in the division of gastroenterology at Penn Medicine, discusses some of the reasons for the increasing incidence of esophageal cancer and Barrett's esophagus in the U.S. What latest developments can help physicians optimally manage patients with these GI disorders? Dr. Falk also discusses the role of motility in acid reflux, and reviews current medication options for the condition. Dr. Lee Freedman hosts.