For the very first time, two previous European Society of Cardiology (ESC) guidelines have been combined into a single document. There can be different forms of presentation, but they’re all a part of the acute coronary syndrome (ACS) spectrum. To gain more insight into these guidelines, join Dr. Borja Ibáñez, combines research activities as Director of Clinical Research of the National Center for Cardiovascular Research in Spain with clinical activities as Interventional Cardiologist at Hospital Fundación Jiménez Díaz, Madrid, Spain.