Though innovations in surgical technology and anesthetic techniques have greatly improved the outlook following cardiac surgery, we must remain attentive to the possibility of post-operative complications. One area of concern includes adverse neurologic outcomes. Dr. Jose Biller, professor of neurology and neurological surgery at the Loyola University Chicago Stritch School of Medicine and chair of neurology at Loyola University Health System, talks with host Dr. Mark Nolan Hill about the key considerations for evaluating cognitive changes following a cardiac procedure. Excluding the most evident post-operative neurologic sequelae, how should we proceed in determining that there is a real problem?