Emerging Insights into the Immunologic Subtypes of Atopic Dermatitis

Dr. Neal Bhatia (00:07):

Hi, I am Dr. Dr. Neal Bhatia. I'm the chief medical editor of Practical Dermatology and director of clinical dermatology at Therapeutics Clinical Research in San Diego, California.

(00:16):

When we think of atopic dermatitis, there are many different subtypes, many different genetic variations, many different presentations, and a lot of it comes back to the building blocks of the, obviously, Th2 pathway with some overlap of the Th17 pathway. Throw in a little bit of interleukin-22, TSLP, OX40, and you have a whole cytokine soup that makes what many patients would say, looks like eczema, what dermatologists call atopic dermatitis, and many of the parents of patients call a struggle.

(00:48):

With that comes with, again, the variations of the different subtypes and the phenotypes that go with atopic dermatitis. But in the end, the building blocks for many of them tend to be the same.