This week, Mark and Margaret speak with Dr. Eric Green, Director of the National Human Genome Research Institute, one of the 27 Institutes at NIH. They have launched a new program called Big Data to Knowledge, or BD2K, which seeks to create better platforms for storing and sharing the large volumes of big data that have emerged in the world of scientific research since the mapping of the human genome. Dr. Green also talks about the threats to future research from young scientists struggling to achieve in a climate of reduced grant funding nationwide.