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Enhancing Treatment Strategies With Molecular Approaches in HER2+ Gastrointestinal Cancers 

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  • Overview

    Join us for a CME online broadcast replay of a live satellite symposium from ESMO GI 2024, where experts discuss strategies to overcome barriers to implementing a collaborative, biomarker-based approach in precision oncology for HER2+ GI cancers. Learn how to individualize therapeutic planning and sequencing for patients with HER2+ gastric/GEJ cancers and improve response and durability in mCRC with HER2-directed therapies. The symposium also covers the role of genomic profiling in guiding treatment decisions for HER2+ BTC and emphasizes the importance of interprofessional collaboration in managing adverse events associated with HER2-directed therapies in patients with GI cancer.  

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.  

    Host:
    Josep Tabernero, MD, PhD
    Head, Medical Oncology Department
    Director, Vall d’Hebron Institute of Oncology (VHIO)
    Professor of Medicine, UVic-UCC
    Vall d’Hebron University Hospital (HUVH)
    Barcelona, Spain 

    Dr. Tabernero has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months:
    Consulting Fees: Alentis Therapeutics, AstraZeneca, Aveo Oncology, Boehringer Ingelheim, Cardiff Oncology, CARsgen Therapeutics, Chugai, Daiichi Sankyo, Inc., F. Hoffmann-La Roche Ltd, Genentech Inc, hC Bioscience, Ikena Oncology, Immodulon Therapeutics, Inspirna Inc, Lilly, Menarini, Merck Serono, Merus, Mirati, MSD, NeoPhore, Novartis, Ona Therapeutics, Orion Biotechnology, Peptomyc, Pfizer, Pierre Fabre, Samsung Bioepis, Sanofi, Scandion Oncology, Scorpion Therapeutics, Seattle Genetics, Servier, Sotio Biotech, Taiho, Takeda Oncology, Tolremo Therapeutics 
    Ownership: 1TRIALSP, Alentis Therapeutics, Oniria Therapeutics, Pangaea Oncology  

    Faculty:
    Sara Lonardi, MD 
    Chief, Oncology Unit 3
    Veneto Institute of Oncology – IRCCS 
    Padua, Italy 

    Dr. Lonardi has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months: 
    Consulting Fees: Amgen, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Daiichi Sankyo, Inc., Incyte, Lilly, Merck Serono, MSD, Pierre Fabre, Roche, Rottapharm, Servier, Takeda
    Research: Amgen, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Daiichi Sankyo, Hutchinson, Incyte, Merck Serono, Mirati, MSD, Pfizer, Roche, Servier 

    Zev A. Wainberg, MD
    Co-Director, UCLA GI Oncology Program
    Professor of Medicine
    University of California, Los Angeles 
    Los Angeles, CA, USA  

    Dr. Wainberg has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months: 
    Consulting Fees: Alligator, Amgen, Arcus, Astellas, AstraZeneca, Bayer, BMS, Daiichi Sankyo, Inc., Gilead, Ipsen, Janssen, Merck, Novartis, Regeneron, Roche/Genentech   
    Research: Amgen, Arcus, AstraZeneca, BMS, Merck, Novartis 

     Reviewers/Content Planners/Authors: 

    • Brad Bongiovanni, ND, has nothing to disclose.  
    • Cindy Davidson has nothing to disclose.  
    • Ann Early has nothing to disclose.  
    • Wendy Engelsma has nothing to disclose.  
    • Andrea Mathis has nothing to disclose. 
    • Brian P. McDonough, MD, FAAFP, has nothing to disclose. 
    • Bing-E Xu, PhD, has nothing to disclose. 
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:  

    • Develop strategies to overcome accessibility and implementation barriers for a collaborative, biomarker-based approach to the precision oncology treatment of GI cancers 
    • Individualize therapeutic planning and sequencing in patients with HER2+ gastric/GEJ cancers 
    • Identify the role of HER2-directed therapies to improve response and durability after disease progression on first-line therapy in patients with mCRC 
    • Contextualize the data on genomic profiling to guide treatment decisions in patients with HER2+ BTC 
    • Utilize interprofessional collaboration to hasten the recognition, monitoring, and management of adverse events seen with HER2-directed therapies in patients with GI cancers  
  • Target Audience

    This activity has been designed to meet the educational needs of medical oncologists and pathologists as well as all other physicians, physician assistants, nurse practitioners, nurses, pharmacists, and healthcare providers involved in managing patients with gastrointestinal cancers. 

  • Accreditation and Credit Designation Statements

    In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    The American Medical Association has an agreement of mutual recognition of continuing medical education (CME) credits with the European Union of Medical Specialists (UEMS), the accreditation body for European countries. Physicians interested in converting AMA PRA Category 1 CreditsTM to UEMS-European Accreditation Council for Continuing Medical Education CME credits (ECMECs) should contact the UEMS at mutualrecognition@uems.eu.  

    Global Learning Collaborative (GLC) designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

    Global Learning Collaborative (GLC) designates this activity for 1.0 nursing contact hour. Nurses should claim only the credit commensurate with the extent of their participation in the activity. 

    Global Learning Collaborative (GLC) has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. Approval is valid until August 7, 2025. PAs should claim only the credit commensurate with the extent of their participation in the activity.   

    Global Learning Collaborative (GLC) designates this activity for 1.0 contact hour/0.1 CEUs of pharmacy contact hours.

    The Universal Activity Number for this program is JA0006235-0000-24-085-H01-P. This learning activity is knowledge-based. Your CE credits will be electronically submitted to the NABP upon successful completion of the activity. Pharmacists with questions can contact NABP customer service (custserv@nabp.net).  

  • Provider(s)/Educational Partner(s)


    Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties. 
     

    Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the best education in the most impactful manner and to verify its results with progressive outcomes research.   

  • Commercial Support

    This activity is supported by an independent educational grant from Daiichi Sankyo, Inc. 

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to access a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site. 

    Reproduction Prohibited 
    Reproduction of this materialis not permitted without written permission from the copyright owner. 

  • System Requirements

    • Supported Browsers (2 most recent versions):
      • Google Chrome for Windows, Mac OS, iOS, and Android
      • Apple Safari for Mac OS and iOS
      • Mozilla Firefox for Windows, Mac OS, iOS, and Android
      • Microsoft Edge for Windows
    • Recommended Internet Speed: 5Mbps+

  • Publication Dates

    Release Date:

    Expiration Date:

Recommended
Details
Presenters
Related
Comments
  • Overview

    Join us for a CME online broadcast replay of a live satellite symposium from ESMO GI 2024, where experts discuss strategies to overcome barriers to implementing a collaborative, biomarker-based approach in precision oncology for HER2+ GI cancers. Learn how to individualize therapeutic planning and sequencing for patients with HER2+ gastric/GEJ cancers and improve response and durability in mCRC with HER2-directed therapies. The symposium also covers the role of genomic profiling in guiding treatment decisions for HER2+ BTC and emphasizes the importance of interprofessional collaboration in managing adverse events associated with HER2-directed therapies in patients with GI cancer.  

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.  

    Host:
    Josep Tabernero, MD, PhD
    Head, Medical Oncology Department
    Director, Vall d’Hebron Institute of Oncology (VHIO)
    Professor of Medicine, UVic-UCC
    Vall d’Hebron University Hospital (HUVH)
    Barcelona, Spain 

    Dr. Tabernero has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months:
    Consulting Fees: Alentis Therapeutics, AstraZeneca, Aveo Oncology, Boehringer Ingelheim, Cardiff Oncology, CARsgen Therapeutics, Chugai, Daiichi Sankyo, Inc., F. Hoffmann-La Roche Ltd, Genentech Inc, hC Bioscience, Ikena Oncology, Immodulon Therapeutics, Inspirna Inc, Lilly, Menarini, Merck Serono, Merus, Mirati, MSD, NeoPhore, Novartis, Ona Therapeutics, Orion Biotechnology, Peptomyc, Pfizer, Pierre Fabre, Samsung Bioepis, Sanofi, Scandion Oncology, Scorpion Therapeutics, Seattle Genetics, Servier, Sotio Biotech, Taiho, Takeda Oncology, Tolremo Therapeutics 
    Ownership: 1TRIALSP, Alentis Therapeutics, Oniria Therapeutics, Pangaea Oncology  

    Faculty:
    Sara Lonardi, MD 
    Chief, Oncology Unit 3
    Veneto Institute of Oncology – IRCCS 
    Padua, Italy 

    Dr. Lonardi has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months: 
    Consulting Fees: Amgen, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Daiichi Sankyo, Inc., Incyte, Lilly, Merck Serono, MSD, Pierre Fabre, Roche, Rottapharm, Servier, Takeda
    Research: Amgen, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Daiichi Sankyo, Hutchinson, Incyte, Merck Serono, Mirati, MSD, Pfizer, Roche, Servier 

    Zev A. Wainberg, MD
    Co-Director, UCLA GI Oncology Program
    Professor of Medicine
    University of California, Los Angeles 
    Los Angeles, CA, USA  

    Dr. Wainberg has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months: 
    Consulting Fees: Alligator, Amgen, Arcus, Astellas, AstraZeneca, Bayer, BMS, Daiichi Sankyo, Inc., Gilead, Ipsen, Janssen, Merck, Novartis, Regeneron, Roche/Genentech   
    Research: Amgen, Arcus, AstraZeneca, BMS, Merck, Novartis 

     Reviewers/Content Planners/Authors: 

    • Brad Bongiovanni, ND, has nothing to disclose.  
    • Cindy Davidson has nothing to disclose.  
    • Ann Early has nothing to disclose.  
    • Wendy Engelsma has nothing to disclose.  
    • Andrea Mathis has nothing to disclose. 
    • Brian P. McDonough, MD, FAAFP, has nothing to disclose. 
    • Bing-E Xu, PhD, has nothing to disclose. 
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:  

    • Develop strategies to overcome accessibility and implementation barriers for a collaborative, biomarker-based approach to the precision oncology treatment of GI cancers 
    • Individualize therapeutic planning and sequencing in patients with HER2+ gastric/GEJ cancers 
    • Identify the role of HER2-directed therapies to improve response and durability after disease progression on first-line therapy in patients with mCRC 
    • Contextualize the data on genomic profiling to guide treatment decisions in patients with HER2+ BTC 
    • Utilize interprofessional collaboration to hasten the recognition, monitoring, and management of adverse events seen with HER2-directed therapies in patients with GI cancers  
  • Target Audience

    This activity has been designed to meet the educational needs of medical oncologists and pathologists as well as all other physicians, physician assistants, nurse practitioners, nurses, pharmacists, and healthcare providers involved in managing patients with gastrointestinal cancers. 

  • Accreditation and Credit Designation Statements

    In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    The American Medical Association has an agreement of mutual recognition of continuing medical education (CME) credits with the European Union of Medical Specialists (UEMS), the accreditation body for European countries. Physicians interested in converting AMA PRA Category 1 CreditsTM to UEMS-European Accreditation Council for Continuing Medical Education CME credits (ECMECs) should contact the UEMS at mutualrecognition@uems.eu.  

    Global Learning Collaborative (GLC) designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

    Global Learning Collaborative (GLC) designates this activity for 1.0 nursing contact hour. Nurses should claim only the credit commensurate with the extent of their participation in the activity. 

    Global Learning Collaborative (GLC) has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. Approval is valid until August 7, 2025. PAs should claim only the credit commensurate with the extent of their participation in the activity.   

    Global Learning Collaborative (GLC) designates this activity for 1.0 contact hour/0.1 CEUs of pharmacy contact hours.

    The Universal Activity Number for this program is JA0006235-0000-24-085-H01-P. This learning activity is knowledge-based. Your CE credits will be electronically submitted to the NABP upon successful completion of the activity. Pharmacists with questions can contact NABP customer service (custserv@nabp.net).  

  • Provider(s)/Educational Partner(s)


    Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties. 
     

    Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the best education in the most impactful manner and to verify its results with progressive outcomes research.   

  • Commercial Support

    This activity is supported by an independent educational grant from Daiichi Sankyo, Inc. 

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to access a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site. 

    Reproduction Prohibited 
    Reproduction of this materialis not permitted without written permission from the copyright owner. 

  • System Requirements

    • Supported Browsers (2 most recent versions):
      • Google Chrome for Windows, Mac OS, iOS, and Android
      • Apple Safari for Mac OS and iOS
      • Mozilla Firefox for Windows, Mac OS, iOS, and Android
      • Microsoft Edge for Windows
    • Recommended Internet Speed: 5Mbps+

  • Publication Dates

    Release Date:

    Expiration Date:

Schedule14 Oct 2024