This year's conference will focus on one key aspect of kidney care: transplantation. Get the latest updates from nephrology experts from around the world.
The American Society of Nephrology’s annual Kidney Week is featuring insights into all areas of kidney care. But many sessions aim to take a look at one key component: kidney transplants. And in one of the first sessions at this year’s event, transplant experts will discuss chronic allograft injury.
In a session titled “Why Allografts Fail: Clinical, Histopathological, and Molecular Approach to Chronic Allograft Injury, Including the Barbara T. Murphy, MB BAO BCh, Endowed Lectureship,” nephrologists from around the world will learn more about chronic allograft injury, a common complication in kidney transplantation that can occur in 40 to 505% of protocol biopsies performed one year after transplantation. While research has shown that early changes in graft histology can lead to longer-term graft survival, what do nephrologists need to do in the event of a failed allograft?
The session will focus on three primary areas:
- Molecular diagnostic methods such as cell-free DNA, gene transcripts, and the molecular microscope
- Updates on chronic antibody-mediated rejection and chronic T cell-mediated rejection
- Clinical approaches to a failing allograft and the etiological factors that could lead to a chronic allograft injury
A Transplant Expert’s Perspective on Graft Long-Term Outcomes
The session will be made up of four individual presentations, including the Barbara T. Murphy, MB BAO BCh, Endowed Lectureship titled “Improving Kidney Graft Long-Term Outcomes: Lessons Learned and New Perspectives.”
In this presentation, Dr. Roslyn B. Mannon, a former President of the American Society of Transplantation, will share her experiences—and the lessons she’s learned along the way—on kidney transplantation and the mechanisms of chronic graft injury.
Dr. Mannon is a Professor of Medicine, Pathology, and Microbiology; Vice Chair for Academic Development and Research Mentoring; and Associate Chief of Nephrology for research at the University of Nebraska Medical Center.
She’s contributed to approximately 200 peer-reviewed publications on the mechanisms of chronic allograft failure following transplantation, posttransplant complications, and immune monitoring.
The other presentations to be featured at this session include:
- “Molecular Approaches to Chronic Allograft Injury,” led by Dr. Valeria R. Mas, a Professor in the Department of Surgery in the School of Medicine at the University of Maryland in Baltimore
- “Update to Banff Histopathological Diagnosis of Chronic Allograft Injury” led by Dr. Michael Mengel, an Associate Professor in the Department of Laboratory Medicine and Pathology at the University of Alberta in Canada
- “Contributions of Antibody-Mediated and Cell-Mediated Alloimmunity to Chronic Graft Injury,” led by Dr. Peter W. Nickerson, a Distinguished Professor of Internal Medicine and Immunology and the Vice-Dean Research in the Rady Faculty of Health Sciences at the University of Manitoba in Canada