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ReachMD Faculty

Public Profile

Ivy Ka Man Law, PhD
Ivy Ka Man Law, PhD
  • Assistant Project Scientist
  • Center for Inflammatory Bowel Diseases
  • David Geffen School of Medicine
  • UCLA
Dr. Law received her PhD in Department of Pharmacology and Pharmacy in Li Ka Shing Faculty of Medicine at the University of Hong Kong. Her PhD thesis focused on the role of lipocalins in the development of insulin resistance. During her PhD studies, she also identifies possible interacting partners of Sirtuins, which play important roles in aging and metabolism, using proteomics tools. Dr. Law joined Center for Inflammatory Bowel Diseases in 2010. Her post-doctoral research is on cellular mechanism of neurotensin receptor signaling, neurotensin-induced microRNAs expression and pro-inflammatory responses in colonocytes. Currently, using in vitro and different mouse models, Dr. Law has expanded her work to study the role of aftiphilin, one of the gene targets from her post-doctoral research work, on colitis-associated proinflammatory response and its role in regulating intestinal permeability. Other ongoing projects include the studies of long non-coding RNAs (lncRNAs) and exosome-mediated intercellular communication associated with colitis. Understanding neurotensin signaling-associated lncRNA expression in inflamed colonocytes and colonic tissues can contribute to our knowledge in the functional significance of lncRNAs in G protein-coupled receptor (GPCR)-mediated signaling pathways during colitis development. Studies in the functional role of non-coding RNAs carried by exosomes secreted from colonocytes and colonic tissues can provide insights to the possible communications and interactions between different cell/tissue types during colitis development.
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