The Intersection of TSLP Biomarkers and CT Imaging in Severe Asthma

A new study on severe asthma links elevated sputum TSLP with type 2-high inflammation and CT-visible mucus plugs, sharpening phenotype classification and prioritizing biologic strategies.

Sputum TSLP protein was higher and correlated with blood and airway eosinophilia alongside type 2 sputum gene signatures, supporting its role as an airway immune-activation marker.

CT evidence of mucus plugging and airway remodeling clustered with the TSLP-high, type 2-high profile, suggesting structural consequences that may predict treatment response and disease severity.

Integrating sputum TSLP into multidisciplinary assessment and monitoring could refine biologic selection while larger-cohort validation and implementation pathways are established.