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Systemic Thrombolysis of Acute Portal Venous System Thrombosis in Patients with Liver Cirrhosis: A Pilot Study

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05/28/2024
eurekalert.org

The prevalence of Portal Vein Thrombosis (PVT) varies significantly at different stages of liver disease: 10% in compensated patients, 17% in decompensated patients, 9% in those with acute decompensated cirrhosis, and 2-26% in post-liver transplant patients.

A recent study aimed to evaluate the effectiveness and safety of systemic thrombolysis for acute portal vein thrombosis in patients with liver cirrhosis.

Ten compensated cirrhotic patients with acute portal vein thrombosis were examined using abdominal ultrasound with color Doppler and contrast-enhanced CT scans. All patients received continuous intravenous infusions of recombinant tissue plasminogen activator (r-tPA) and low molecular weight heparin (LMWH) for up to 7 days. Patients were monitored for clinical improvement and radiological changes using abdominal ultrasound with color Doppler and contrast-enhanced CT scans.

The treatment was well-tolerated by all patients. After seven days, six patients (60%) had full recanalization of the portal vein, three patients (30%) had partial recanalization, and one patient (10%) had no recanalization.

Preliminary data suggest that systemic thrombolytic therapy combined with low molecular weight heparin is a safe and effective treatment for PVT over a short period, with no significant side effects.

Read this research here; https://bit.ly/3yvLqdD



Journal

The Open Biomarkers Journal

Article Title

Systemic Thrombolysis of Acute Portal Venous System Thrombosis in Patients with Liver Cirrhosis: A Pilot Study

Article Publication Date

24-Apr-2024

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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