Systematic Review Supports Efficacy of Targeted HA Chin Injection Strategy

Chin augmentation with hyaluronic acid (HA) fillers has become a cornerstone of lower facial contouring. In a systematic review and meta-analysis published online in Aesthetic Plastic Surgery, the authors evaluated the safety and efficacy of a two-three-point injection technique for chin enhancement.

The authors identified 3 randomized controlled trials and 3 cohort studies through searches of PubMed, Scopus, Web of Science, and Embase through June 2025. Statistical analyses were conducted using fixed- or random-effects models in Stata/MP version 17, depending on heterogeneity.

The pooled Global Aesthetic Improvement Scale (GAIS) responder rate for chin enhancement was 94% (effect size [ES], 0.94; 95% CI, 0.92-0.97; P < 0.001). Injection site reactions (ISRs) were common but generally mild. Firmness occurred in 91% of patients (95% CI, 88%-94%), and swelling in 87% (95% CI, 84%-90%). The overall adverse event rate was 7.92% (95% CI, 6.31%-9.53%).

Based on pooled data, the authors concluded that the two-three-point HA injection technique for chin enhancement demonstrates high efficacy with acceptable safety. They note that outcomes were consistent across included studies, although the analysis incorporated both randomized and observational data. The journal designates the study as Level of Evidence V.