Study Supports PLLA-SCA for Décolletage Rejuvenation

Poly-L-lactic acid for injectable suspension (PLLA-SCA; Sculptra, Galderma) was effective and well tolerated for correction of moderate to severe décolletage wrinkles using either 8-mL or 17-mL reconstitution volumes, according to findings from a 9-month, open-label study published in the Journal of Drugs in Dermatology.

The randomized study included 30 women with moderate or severe wrinkles on the Galderma Décolletage Scale (GDS). Participants were assigned 1:1 to receive PLLA-SCA reconstituted with either 8 mL or 17 mL sterile water for injection, plus 1 mL of 2% lidocaine. Patients could receive up to 4 treatments, administered 1 month apart.

At month 9, the study’s primary endpoint, most participants achieved at least a 1-point improvement on investigator-assessed GDS scores. Improvement was reported in 93.8% of patients in the 8-mL group and 78.6% of patients in the 17-mL group. At month 6, at least 93% of participants in both groups also showed improvement.

Global Aesthetic Improvement Scale findings were similarly favorable, with more than 90% of participants in both groups rated as improved at months 6 and 9. Patient-reported outcomes also supported durability of response: more than 90% of participants in both groups reported satisfaction with the appearance of their wrinkles by month 3, and satisfaction was sustained through the study. More than 80% of participants reported satisfaction with skin texture, smoothness, and radiance at months 6 and 9.

One adverse event was considered treatment related. No adverse events were serious or led to study discontinuation.

“Treatment of the décolletage area with PLLA-SCA was effective and well tolerated with both reconstitution volumes, with high subject satisfaction,” the authors wrote.

Source

Joseph J, Palm MD, Bråsäter D, Wolgast C, Weinberg F, Prygova I. Safety and effectiveness of two reconstitution volumes of poly-L-lactic acid for correction of décolletage wrinkles. J Drugs Dermatol. 2026;25(6):553.