practicaldermatology.com
A comparative analysis of dermal mesenchymal stem cell exosomes from healthy human skin and psoriatic lesions revealed 13 differential proteins, according a research published in Current Molecular Medicine.
Researchers at Shanxi Medical University published “Proteomic Analysis of Mesenchymal Stem Cell-derived Exosomes in Psoriasis” this month.
“This study aims to investigate the unique proteins in exosomes from mesenchymal stem cells derived from psoriatic lesions and compare them with those from healthy human skin,” they wrote. “It seeks to identify potential regulatory factors that may influence the differential effects observed in these exosomes.”
Extracted exosomes were analyzed through label-free quantitative proteomics to identify differential proteins. Bioinformatics analyses, including GO and KEGG enrichment, were conducted.
Notable proteins identified as being associated with the inflammatory mechanisms of psoriasis included B2R3D5, MFGE8, and MFAP5.
“These finding offer valuable insights for further exploration of the inflammatory processes in psoriasis,” the authors wrote.