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A recent study from Drexel University’s A.J. Drexel Autism Institute has revealed that standardized autism screening during pediatric well-child visits leads to earlier identification of children at high likelihood for autism, including those with milder or less obvious symptoms. Published in the Journal of the American Academy of Child & Adolescent Psychiatry, this randomized, multi-site trial is the first of its kind to evaluate the impact of universal, high-fidelity autism screening in primary care settings.
The study analyzed data from 31 pediatric practices across three regions: Philadelphia, Pennsylvania; Storrs, Connecticut; and Sacramento, California. Practices were randomly assigned to either implement the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) as a standardized screening tool or to continue with "usual care," which often involved a combination of inconsistent screening practices or reliance on clinical judgment.
The differences between the groups were significant. Practices using the M-CHAT-R/F referred 186 children for diagnostic evaluation, representing 7.4% of their patient pool, at an average age of 20.6 months. By contrast, practices in the usual care group referred only 39 children, or 1.5% of their patients, at an older average age of 23.6 months. According to lead author Giacomo Vivanti, PhD, “the screener was administered and scored the same way for every child,” which led to earlier and more frequent referrals for diagnostic evaluations.
Children referred via standardized screening also showed a wider range of symptoms, including subtle language and cognitive impairments, compared to children referred through usual care. This suggests that standardized screening helps identify children who might otherwise be overlooked due to the absence of more obvious impairments.
Early diagnosis is critical because it enables children to access autism-specific interventions during developmental periods when they are most effective. Diana Robins, PhD, director of the Autism Institute and creator of the M-CHAT-R/F, explained that earlier identification can significantly improve lifelong outcomes. “The earlier identification of autism allows for autism-specific early intervention at a younger age, which improves outcomes across the rest of their lives,” she said.
The study highlights a persistent gap between evidence-based guidelines and real-world practice. The American Academy of Pediatrics (AAP) has recommended universal, standardized autism screening during 18- and 24-month well-child visits for nearly 20 years. However, community implementation often lags, with many providers still relying on clinical judgment or inconsistent screening methods. Robins and Vivanti emphasized the importance of adhering to standardized protocols to ensure that all children are properly screened and referred when needed.
The findings underscore the importance of integrating universal, high-fidelity autism screening into routine pediatric care. Standardized screening tools like the M-CHAT-R/F not only increase the likelihood of identifying children with autism but also do so at a younger age, when interventions are most beneficial. Policymakers and healthcare providers may need to prioritize resources and training to ensure consistent implementation of these tools.
By identifying children earlier and more accurately, universal screening practices could help close the gap between recommended best practices and real-world care, ultimately improving outcomes for children with autism and their families.