Review Examines Dermatologic Effects of Rapid Weight Loss

Rapid weight loss associated with bariatric surgery, glucagon-like peptide-1 receptor agonists (GLP-1 RA), and intensive lifestyle interventions may contribute to dermatologic and structural changes that extend beyond reduced body size, according to a narrative review in the Journal of Cosmetic Dermatology.

The review examined English-language literature published from 2000 to 2025 on soft tissue changes linked to rapid weight loss. The authors reported that rapid intentional weight loss can affect collagen, elastic fibers, adipose tissue, muscle mass, and skeletal integrity, potentially contributing to decreased skin firmness, visible soft tissue laxity, muscle loss, and reduced bone density.

Management strategies described in the review include nutritional optimization, resistance-based physical activity, energy-based devices, biostimulatory injectables, and surgical procedures for advanced cases. Regenerative therapies are also being studied, although the review characterized these approaches as emerging rather than established.

The authors noted that dermatologists are increasingly likely to encounter cosmetic and structural concerns related to rapid weight loss as weight-loss interventions become more common. The review supports a multidisciplinary, evidence-informed approach to evaluation and management.

“As rapid weight loss becomes increasingly common, dermatologists are encountering a broader range of cosmetic and structural concerns,” the authors wrote. “A multidisciplinary, evidence-informed approach is critical for addressing these issues and improving patient outcomes.”