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Reporting on Invasive Lobular Breast Cancer in Clinical Trials: A Systematic Review - npj Breast Cancer

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07/17/2024
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  1. Christgen, M. et al. Lobular breast cancer: histomorphology and different concepts of a special spectrum of tumors. Cancers13, 3695 (2021).

    ArticleCASPubMedPubMed Central Google Scholar

  2. Desmedt, C. et al. Genomic characterization of primary invasive lobular breast cancer. J. Clin. Oncol.34, 1872–1880.

  3. Ciriello, G. et al. Comprehensive molecular portraits of invasive lobular breast cancer. Cell163, 506–519 (2015).

    ArticleCASPubMedPubMed Central Google Scholar

  4. Richard, F. et al. Characterization of stromal tumor-infiltrating lymphocytes and genomic alterations in metastatic lobular breast cancer. Clin. Cancer Res.26, 6254–6265 (2020).

    ArticleCASPubMed Google Scholar

  5. Van Baelen, K. et al. Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer. Ann Oncol. https://doi.org/10.1016/J.ANNONC.2022.05.006 (2022).

  6. Christgen, M. et al. Lobular breast cancer: clinical, molecular and morphological characteristics. Pathol. Res Pract.212, 583–597 (2016).

    ArticleCASPubMed Google Scholar

  7. Tan, P. H. et al. The 2019 World Health Organization classification of tumours of the breast. Histopathology77, 181–185 (2020).

    ArticlePubMed Google Scholar

  8. Christgen, M. et al. Differential impact of prognostic parameters in hormone receptor–positive lobular breast cancer. Cancer126, 4847–4858 (2020).

    ArticleCASPubMed Google Scholar

  9. Metzger, O. et al. Clinical utility of MammaPrint testing in invasive lobular carcinoma: results from the MINDACT phase III trial. Eur. J. Cancer138, S5–S6 (2020).

  10. Mouabbi, J. A., Hassan, A., Lim, B., Hortobagyi, G. N., Tripathy, D. & Layman, R. M. Invasive lobular carcinoma: an understudied emergent subtype of breast cancer. Breast Cancer Res. Treat.193, 253–264 (2022).

  11. Metzger, O. et al. Relative effectiveness of letrozole compared with tamoxifen for patients with lobular carcinoma in the BIG 1-98 trial. J. Clin. Oncol.33, 2772–U85 (2015).

    Article Google Scholar

  12. Timbres, J. et al. Survival outcomes in invasive lobular carcinoma compared to oestrogen receptor-positive invasive ductal carcinoma. Cancers13, 3036 (2021).

    ArticleCASPubMedPubMed Central Google Scholar

  13. Trapani, D. et al. Benefit of adjuvant chemotherapy in patients with lobular breast cancer: a systematic review of the literature and metanalysis. Cancer Treat. Rev.97, 102205 (2021).

    ArticleCASPubMed Google Scholar

  14. Bradley, R. et al. Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials. Lancet Oncol.23, 382 (2022).

    ArticleCAS Google Scholar

  15. Harbeck, N. et al. Breast cancer. Nat. Rev. Dis. Prim.5, 1–31 (2019).

    Google Scholar

  16. McCart Reed, A. E., Kutasovic, J. R., Lakhani, S. R. & Simpson, P. T. Invasive lobular carcinoma of the breast: morphology, biomarkers and’omics. Breast Cancer Res.17. https://doi.org/10.1186/s13058-015-0519-x (2015).

  17. Abel, M. K. et al. Decreased enrollment of patients with advanced lobular breast cancer compared to ductal breast cancer in interventional clinical trials. J. Clin. Oncol.39, 1092–1092 (2021).

    Article Google Scholar

  18. Schwartz, L. H. et al. RECIST 1.1 - Standardisation and disease-specific adaptations: perspectives from the RECIST Working Group. Eur. J. Cancer62, 138–145 (2016).

    ArticlePubMedPubMed Central Google Scholar

  19. Eisenhauer, E. A. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). https://doi.org/10.1016/j.ejca.2008.10.026.

  20. Sledge, G. W. et al. MONARCH 2: Abemaciclib in combination with fulvestrant in women with HR+/HER2-advanced breast cancer who had progressed while receiving endocrine therapy. J. Clin. Oncol.35, 2875–2884 (2017).

    ArticleCASPubMed Google Scholar

  21. Zhang, Q. Y. et al. MONARCH plus: abemaciclib plus endocrine therapy in women with HR+/HER2– advanced breast cancer: the multinational randomized phase III study. Ther. Adv. Med. Oncol.12. https://doi.org/10.1177/1758835920963925 (2020).

  22. Johnston, S. et al. MONARCH 3 final PFS: a randomized study of abemaciclib as initial therapy for advanced breast cancer. NPJ Breast Cancer5, 5 (2019).

    ArticlePubMedPubMed Central Google Scholar

  23. Finn, R. S. et al. Overall survival (OS) with first-line palbociclib plus letrozole (PAL + LET) versus placebo plus letrozole (PBO + LET) in women with estrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer (ER+/HER2− ABC): analyses from PALOMA-2. J. Clin. Oncol.40 LBA1003–LBA1003 (2022).

  24. Xu, B. et al. Palbociclib plus letrozole versus placebo plus letrozole in Asian postmenopausal women with oestrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer: Primary results from PALOMA-4. Eur. J. Cancer175, 236–245 (2022).

    ArticleCASPubMed Google Scholar

  25. Ferlicot, S. et al. Wide metastatic spreading in infiltrating lobular carcinoma of the breast. Eur. J. Cancer40, 336–341 (2004).

    ArticleCASPubMed Google Scholar

  26. Vincent-Salomon, A. et al. Lobular phenotype related to occult-metastatic spread in axillary sentinel node and/or bone marrow in breast carcinoma. Eur. J. Cancer45, 1979–1986 (2009).

    ArticlePubMed Google Scholar

  27. Johnson, K., Sarma, D. & Hwang, E. S. Lobular breast cancer series: Imaging. Breast Cancer Res.17, 94 (2015).

    ArticlePubMedPubMed Central Google Scholar

  28. Page, M. J. et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. J. Clin. Epidemiol.134, 178–189 (2021).

    ArticlePubMed Google Scholar

  29. Nagayama, A., Vidula, N. & Bardia, A. Novel therapies for metastatic triple-negative breast cancer: spotlight on immunotherapy and antibody-drug conjugates. Oncology (Williston Park)35, 249–254 (2021).

    ArticlePubMed Google Scholar

  30. Elliott, M. J. & Cescon, D. W. Development of novel agents for the treatment of early estrogen receptor positive breast cancer. Breast62, S34 (2022).

    ArticlePubMed Google Scholar

  31. Martin, M. & López-Tarruella, S. Emerging therapeutic options for HER2-positive breast cancer. Am. Soc. Clin. Oncol. Educ. Book35, e64–e70 (2016).

  32. Gianni, L. et al. Pathologic complete response (pCR) to neoadjuvant treatment with or without atezolizumab in triple-negative, early high-risk and locally advanced breast cancer: NeoTRIP Michelangelo randomized study. Ann. Oncol.33, 534–543 (2022).

    ArticleCASPubMed Google Scholar

  33. Mittendorf, E. A. et al. Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial. Lancet396, 1090–1100 (2020).

    ArticleCASPubMed Google Scholar

  34. Guan, Z. et al. Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2–overexpressing metastatic breast cancer. J. Clin. Oncol.31, 1947–1953 (2013).

    ArticleCASPubMed Google Scholar

  35. von Minckwitz, G. et al. Survival after neoadjuvant chemotherapy with or without bevacizumab or everolimus for HER2-negative primary breast cancer (GBG 44-GeparQuinto). Ann. Oncol.25, 2363–2372 (2014).

    Article Google Scholar

  36. Untch, M. et al. Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial. Lancet Oncol.13, 135–144 (2012).

    ArticleCASPubMed Google Scholar

  37. Decker, T. et al. Final results from IMPROVE: a randomized, controlled, open-label, two-arm, cross-over phase IV study to determine patients’ preference for everolimus in combination with exemestane or capecitabine in combination with bevacizumab in advanced HR-positive, HER2-negative breast cancer. BMC Cancer20, 286 (2020).

    ArticleCASPubMedPubMed Central Google Scholar

  38. Baselga, J. et al. Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol.18, 904 (2017).

    ArticleCASPubMedPubMed Central Google Scholar

  39. Gao, J. J. et al. CDK4/6 inhibitor treatment for patients with hormone receptor-positive, HER2-negative, advanced or metastatic breast cancer: a US Food and Drug Administration pooled analysis. Lancet Oncol.21, 250–260 (2020).

    ArticleCASPubMed Google Scholar

  40. Gao, J. J. et al. Overall survival in patients with hormone receptor-positive, HER2-negative, advanced or metastatic breast cancer treated with a cyclin-dependent kinase 4/6 inhibitor plus fulvestrant: a US Food and Drug Administration pooled analysis. Lancet Oncol.22, 1573–1581 (2021).

    ArticleCASPubMed Google Scholar

  41. Iorfida, M. et al. Invasive lobular breast cancer: Subtypes and outcome. Breast Cancer Res Treat.133, 713–723 (2012).

    ArticleCASPubMed Google Scholar

  42. De Schepper, M. et al. Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer. Mod. Pathol. https://doi.org/10.1038/S41379-022-01135-2 (2022).

  43. Mouabbi, J. A. et al. Histology-based survival outcomes in hormone receptor-positive metastatic breast cancer treated with targeted therapies. NPJ Breast Cancer8, 131 (2022).

    ArticleCASPubMedPubMed Central Google Scholar

  44. Agostinetto, E. et al. Clinico-molecular characteristics associated with outcomes in breast cancer patients treated with CDK4/6 inhibitors: results from the AURORA Molecular Screening Initiative. J. Clin. Oncol.41, 1019–1019 (2023).

  45. Orlandi, A. et al. Palbociclib plus fulvestrant or everolimus plus exemestane for pretreated advanced breast cancer with lobular histotype in ER+/HER2− patients: a propensity score-matched analysis of a multicenter retrospective patient series. J. Pers. Med.10, 1–11 (2020).

    Article Google Scholar

  46. Agostinetto, E. et al. ROSALINE: a phase II, neoadjuvant study targeting ROS1 in combination with endocrine therapy in invasive lobular carcinoma of the breast. Future Oncol.18, 2383–2392 (2022).

    ArticleCASPubMed Google Scholar

  47. Crizotinib in Lobular Breast, Diffuse Gastric and Triple Negative Lobular Breast Cancer or CDH1-mutated Solid Tumours—Full Text View - ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03620643?cond=NCT03620643&draw=2&rank=1 (accessed 27 Apr 2021).

  48. Hyman, D. et al. HER kinase inhibition in patients with HER2- and HER3-mutant cancers. Nature554, 189–194 (2018).

    ArticleADSCASPubMedPubMed Central Google Scholar

  49. Ma, C. X. et al. The phase II MutHER study of neratinib alone and in combination with fulvestrant in HER2 mutated, non-amplified metastatic breast cancer. Clin. Cancer Res. clincanres.CCR-21-3418-E.2021 (2022).

  50. Voorwerk, L. et al. PD-L1 blockade in combination with carboplatin as immune induction in metastatic lobular breast cancer: the GELATO trial. Nat. Cancer4, 535 (2023).

    ArticleCASPubMedPubMed Central Google Scholar

  51. Kadys, A., Gremke, N., Schnetter, L., Kostev, K. & Kalder, M. Intercontinental comparison of women with breast cancer treated by oncologists in Europe, Asia, and Latin America: a retrospective study of 99,571 patients. J. Cancer Res. Clin. Oncol.149, 7319–7326 (2023).

  52. Hogan, M. P. et al. Comparison of 18F-FDG PET/CT for systemic staging of newly diagnosed invasive lobular carcinoma versus invasive ductal carcinoma. J. Nucl. Med.56, 1674–1680 (2015).

    ArticleCASPubMed Google Scholar

  53. Zugni, F. et al. The added value of whole-body magnetic resonance imaging in the management of patients with advanced breast cancer. PLoS ONE13, e0205251 (2018).

    ArticlePubMedPubMed Central Google Scholar

  54. Bi, W. L. et al. Artificial intelligence in cancer imaging: clinical challenges and applications. CA Cancer J. Clin.69, 127–157 (2019).

    ArticlePubMedPubMed Central Google Scholar

  55. Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin.71, 209–249 (2021).

    ArticlePubMed Google Scholar

  56. Javier-DesLoges, J. et al. Disparities and trends in the participation of minorities, women, and the elderly in breast, colorectal, lung, and prostate cancer clinical trials. Cancer128, 770–777 (2022).

    ArticlePubMed Google Scholar

  57. Sedrak, M. S. et al. Older adult participation in cancer clinical trials: a systematic review of barriers and interventions. CA Cancer J. Clin.71, 78–92 (2021).

    ArticlePubMed Google Scholar

  58. Corrigan, K. L. et al. Exclusion of men from randomized phase III breast cancer clinical trials. Oncologist25, e990–e992 (2020).

    ArticleCASPubMedPubMed Central Google Scholar

  59. Alsaleh, K. et al. Neoadjuvant endocrine therapy with or without palbociclib in low-risk patients: a phase III randomized double-blind SAFIA trial. J. Cancer Res. Clin. Oncol.149, 6171–6179 (2023).

  60. Bundred, N. et al. Combined perioperative lapatinib and trastuzumab in early HER2-positive breast cancer identifies early responders: randomized UK EPHOS-B trial long-term results. Clin. Cancer Res.28, 1323 (2022).

    ArticleCASPubMedPubMed Central Google Scholar

  61. Guarneri, V. et al. Everolimus plus aromatase inhibitors as maintenance therapy after first-line chemotherapy: final results of the phase III randomised MAIN-A (MAINtenance Afinitor) trial. Eur. J. Cancer154, 21–29 (2021).

    ArticleCASPubMed Google Scholar

  62. Fehm, T. et al. HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial. Breast Cancer Res Treat.124, 403–412 (2010).

    ArticleCASPubMed Google Scholar

  63. Willemsen, A. E. C. A. B. et al. Everolimus exposure and early metabolic response as predictors of treatment outcomes in breast cancer patients treated with everolimus and exemestane. Target Oncol.13, 641–648 (2018).

    ArticlePubMed Google Scholar

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