RADIESSE Study Links Calcium Hydroxylapatite to ECM Regeneration

Merz Aesthetics announced new data showing that RADIESSE may support regeneration of multiple extracellular matrix components, including collagen, elastin, decorin, and versican, in human skin.

The 6-month, placebo-controlled biomarker study, published in the Journal of Cosmetic Dermatology, evaluated undiluted and diluted RADIESSE compared with saline placebo. According to the company, collagen increased up to 23-fold versus placebo, while elastin increased by 96%. Decorin and versican, extracellular matrix proteins associated with skin hydration and structure, increased by 82% and 129%, respectively.

RADIESSE and Solar Elastosis Findings

Investigators also reported improvements in ultrasonographic features of solar elastosis at RADIESSE-treated sites at both 3 and 6 months. Solar elastosis is associated with chronic sun damage and contributes to visible changes such as wrinkles, laxity, and crepey skin.

“While previous research has shown that biostimulation with RADIESSE has a positive impact on both collagen and elastin production, the latest evidence published today demonstrates it also supports a broader remodeling process – including notable improvements to sun damaged skin,” said Owen Sunga, MD, executive vice president and head of global medical affairs at Merz Aesthetics.

Study author Gabriela Casabona, MD, said the findings may broaden clinician understanding of RADIESSE’s effects beneath the skin surface.

“Sun damage is one of the most common concerns we see in patients, and the damage itself extends far beyond what’s visible on the surface,” Dr. Casabona said. “Finding that RADIESSE plays a role in addressing ultrasonographic features of solar elastosis adds an important dimension to how we think about this treatment.”

SOURCE 

Merz Aesthetics. New research shows RADIESSE supports substantial regeneration of collagen and key extracellular matrix proteins. News release. Published May 27, 2026.