practicaldermatology.com
Prolonged use of proton pump inhibitor (PPI) or histamine-2 receptor antagonists (H2RA) is associated with the risk of psoriasis among patients with gastrointestinal diseases, according to a new study published in the Korean Journal of Internal Medicine.
The study included 3,662 patients diagnosed with psoriasis between 2002 and 2013 in South Korea’s National Health Insurance Service-National Sample Cohort.
“Our study found a statistically significant association between the prolonged use of acid-suppressive drugs and the development of psoriasis in the Korean population,” the authors wrote. “Specifically, patients with gastrointestinal diseases who used histamine-2 receptor antagonists (H2RA) or proton pump inhibitors (PPI) for extended periods exhibited a higher risk of developing psoriasis. The adjusted odds ratio for psoriasis was 1.89 (95% CI, 1.66-2.17) with long-term use, indicating a clear dose-response relationship.”
The research was published in a January article titled, “Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort.”