New Mnemonic Tool Enhances Early Recognition of Cutaneous Lymphomas

A–F Think MF is a concise mnemonic that highlights key clinical signs prompting earlier recognition of cutaneous T‑cell lymphomas.

Cutaneous T‑cell lymphomas frequently mimic benign dermatoses such as eczema or psoriasis and may be misclassified for extended periods. Those diagnostic delays can limit treatment options and degrade quality of life.

The mnemonic serves as a focused bedside checklist for front-line assessment. A — alopecia or mucinous scalp or follicular density changes; B — body distribution atypical or patchy for common dermatoses; C — clearly fixed patches or plaques; D — documented failure to respond to standard topical or systemic therapies; E — evidence of folliculotropism or characteristic patch morphology; F — findings suggestive of blood involvement or palpable lymphadenopathy. When multiple features cluster, clinicians are prompted to consider early skin biopsy and dermatology referral.

Because misclassification as eczema, psoriasis, or other benign conditions can lead to inappropriate therapy and potential progression, cognitive aids such as this mnemonic are intended to lower the threshold for biopsy and specialist assessment. The practical expectation is earlier tissue diagnosis and faster specialist review when criteria are met.