Multiomic Blood Signatures Forecast Trauma Outcomes: CU Anschutz Report

Investigators at the University of Colorado Anschutz are using longitudinal plasma multiomic profiling to map trauma-related molecular “endotypes” and trajectories and to forecast organ failure and mortality days before complications develop.

The team described profiling more than 1,300 trauma patients over time and positioning molecular signals in blood as a way to anticipate complications days before they occur. Combined proteomics and metabolomics were measured from longitudinal plasma samples, and the modeling integrated multiple omics layers rather than relying on a single modality.

The authors stated that omics markers predicted organ failure and mortality more accurately and efficiently than traditional injury-based measures, presenting this comparison as a central finding.

Initial findings held in a separate cohort of more than 300 trauma patients. In that independent cohort, the approach was described as capable of predicting trauma outcomes with 92% accuracy.

The researchers said they are working to adapt their molecular profiling approach for rapid, point-of-care testing, including in emergency and military settings.