Multimodal RF Approach Improves Facial Wrinkles in Randomized Trial

A multimodal facial rejuvenation treatment combining radiofrequency (RF), microneedle radiofrequency (MNRF), and dynamic muscle stimulation (DMSt) improved facial wrinkles and aesthetic outcomes in a prospective randomized controlled trial published online in Dermatologic Surgery.¹

Researchers evaluated the combined approach in participants with moderate-to-severe facial wrinkles. The investigators designed the treatment to address multiple components of facial aging, which they described as involving the skin, subcutaneous tissue, and facial musculature.

Facial Rejuvenation Outcomes Persist Through 6 Months

Participants assigned to treatment underwent 3 sessions at 1-month intervals using a device combining RF, MNRF, and DMSt. Clinical outcomes and safety were assessed during follow-up, including evaluations at 1, 3, and 6 months after completion of the treatment series.

The investigators reported significant improvements in facial wrinkles and overall appearance at each follow-up point. All treated participants demonstrated improvement on the Global Aesthetic Improvement Scale (GAIS), compared with no improvement among untreated controls (P < .001).

Fitzpatrick-Goldman Wrinkle and Elastosis Scale scores and patient satisfaction also improved following treatment. Although the magnitude of improvement partially diminished during later follow-up, outcomes remained better among treated participants than controls through 6 months.

Adverse events were characterized as mild and transient, and the treatment was reported as well tolerated. The abstract does not provide the number of participants, randomization procedures, specific adverse-event frequencies, device model, treatment parameters, or detailed between-group effect estimates, limiting assessment of the magnitude and generalizability of the findings.

“The combined RF, MNRF, and DMSt approach achieves significant, albeit partial, improvement with a favorable safety profile by targeting both skin and underlying musculature,” the authors concluded.

1. Yu C, Wang Y, Kang H, et al. Multimodal facial rejuvenation using integrated radiofrequency, microneedle radiofrequency, and dynamic muscle stimulation: a prospective randomized controlled trial. Dermatol Surg. Published online September 22, 2026. doi:10.1097/DSS.0000000000005349.