Imaging Study Explores Tissue Repair Dynamics After UltraClear Laser Therapy

Serial line-field confocal optical coherence tomography (LC-OCT) imaging may provide a noninvasive method for visualizing tissue repair following laser-coring procedures, according to findings published in Lasers in Surgery and Medicine.¹

In the technical demonstration study, investigators evaluated sequential wound-healing changes after treatment with the 2910 nm UltraClear Laser-Coring device using a single-subject self-imaging model. Bilateral volar forearms were treated, with one arm receiving a regenerative serum and the contralateral arm treated with petroleum jelly as a comparator. Imaging assessments were performed from Day 1 through Day 18 using dermoscopy and the deepLive LC-OCT system (Damae Medical, Paris, France).

Serial Imaging Demonstrates Progressive Epidermal Repair

Investigators focused on LC-OCT imaging features including keratinocyte migration, nuclear morphology, stratum corneum regeneration, and dermal remodeling patterns surrounding laser-created microchannels.

Serial imaging demonstrated progressive epithelial coverage over treatment channels, with near-complete epidermal continuity observed by Day 4. Hyperreflective stratum corneum-like layering reappeared between Days 4 and 18, suggesting ongoing barrier restoration. The authors also reported nuclear contour and reflectivity changes consistent with expected cellular activation and maturation during healing.

Dermal remodeling features became more apparent later in the observation period. Between Days 8 and 18, investigators observed dermal vessel dilation and increasing collagen fiber definition on LC-OCT imaging. However, no meaningful differences in LC-OCT appearance were identified between the regenerative serum-treated arm and the petroleum jelly comparator site.

“LC-OCT proved effective for documenting the in vivo imaging features associated with UltraClear Laser-Coring treatment,” the authors wrote. “Serial LC-OCT imaging revealed distinct epidermal and dermal healing patterns. This technical demonstration supports the feasibility of using LC-OCT to visualize laser-induced tissue effects in real time.”¹

Reference

1. Characterizing laser-induced wound healing dynamics using line-field confocal optical coherence tomography. Lasers Surg Med. 2026;58(4):303-310. doi:10.1002/lsm.70117