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A groundbreaking study from Mount Sinai Health System has uncovered a new biological communication pathway between the heart and brain that prompts increased sleep after a heart attack, potentially enhancing the recovery process. The research, published in Nature, is the first to show how the heart sends immune signals to the brain to boost sleep, thereby reducing inflammation and aiding healing. This discovery opens up new considerations for post-heart attack care, highlighting sleep as a crucial element in recovery plans for patients.
Led by Dr. Cameron McAlpine, researchers at Mount Sinai’s Cardiovascular Research Institute studied mice models and patients to observe how heart attacks influence sleep patterns. In mouse models, the team found that within hours of a heart attack, immune cells called monocytes travel to the brain, triggering the release of tumor necrosis factor (TNF), a protein that signals neurons in the thalamus to increase sleep. This response produced a three-fold increase in slow-wave sleep, a restorative sleep stage marked by slow brain waves. In further testing, sleep disruption following a heart attack led to heightened stress responses and inflammation, slowing recovery in affected mice.
Human studies supported these findings: Heart attack patients who reported poor sleep in the first month post-attack had a doubled risk of recurrent cardiovascular events within two years compared to those with better sleep. Moreover, patients with good sleep quality demonstrated improved heart function, while poor sleepers showed minimal recovery. These observations underscore the role of sleep in post-cardiac healing and suggest a potential need for sleep-focused interventions.
This research highlights a crucial aspect of cardiac care that often goes overlooked in intensive care and rehabilitation settings, where sleep is frequently disrupted. According to Dr. McAlpine, integrating sleep promotion into post-heart attack care may mitigate inflammation and stress, promoting better outcomes.
Michelle Olive, PhD, from the National Institutes of Health, which funded the study, emphasized the potential of these findings to transform cardiac rehabilitation practices by underscoring sleep’s role in healing. Further clinical studies could deepen understanding and reinforce sleep-centric recovery strategies, shaping future cardiac care to improve patient recovery trajectories.