High-Density Ultrasound Handpiece Shows Promise in Cellulite Treatment

A recent multicenter study published in the Journal of Cosmetic Dermatology reports that a novel synchronous parallel ultrasound system, equipped with a high-density handpiece, significantly improved the appearance of cellulite in most treated patients, with minimal adverse effects.

The prospective, open-label study enrolled 60 adult female subjects aged 23 to 65 who underwent 2 treatment sessions targeting the thighs and/or buttocks. The new device, which delivers controlled thermal energy to the dermis, was designed to stimulate extracellular matrix remodeling—a mechanism previously associated with skin tightening and improvement in cellulite morphology.

Clinical outcomes were assessed using multiple validated measures, including the Cellulite Severity Scale (CSS), Global Aesthetic Improvement Scale (GAIS), and a skin laxity scale. Physician reviewers, blinded to the treatment timeline, evaluated photographs taken before and after treatment.

Findings showed improvement in 91% of treated areas based on GAIS. CSS scores improved by 69%, while skin laxity improved by 53%. Subject satisfaction was reported by 73% of participants, and the mean reported discomfort was moderate, with an average pain score of 4.26 ± 2.33 on the Numerical Scale Response. No serious adverse events occurred during the trial period.

“Cellulite has long been one of the most challenging aesthetic concerns to address,” said Michael Gold, MD, board-certified dermatologist and clinical researcher. “What makes this data compelling is the visible, physician-validated improvement achieved with just two noninvasive Sofwave treatments, offering patients a realistic option that fits into everyday life.”