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A recent study from the University of Montreal and McGill University has identified that hidradenitis suppurativa (HS), a chronic inflammatory skin disorder, is associated with higher health risks for mothers and their children. Published in JAMA Dermatology, the research highlights the significance of HS as a factor in adverse pregnancy outcomes and potential long-term health complications for both mothers and their offspring.
Hidradenitis suppurativa is marked by painful, recurring nodules and abscesses in sweat gland-rich areas, causing chronic inflammation. Elevated pro-inflammatory cytokines associated with HS are believed to increase the risk of pregnancy complications, including preeclampsia, gestational diabetes, and preterm birth. HS is also frequently linked with autoimmune and endocrinologic comorbidities, potentially heightening risks during pregnancy.
The study’s analysis of over 1.3 million deliveries revealed significant findings. Women with HS were found to have a 55% higher risk of hypertensive disorders in pregnancy, a 61% greater risk of developing gestational diabetes, and a 38% increased risk of severe maternal complications compared to those without HS. Additionally, babies born to mothers with HS were observed to have a 28% higher chance of being born prematurely and a 29% greater likelihood of congenital anomalies.
Long-term follow-up data revealed further implications: mothers with HS had more than double the likelihood of hospitalization following pregnancy, while their children faced a 31% higher risk of hospitalization for a range of health conditions over a 16-year period.
These findings underscore the need for increased awareness and proactive management of pregnant individuals with HS. Researchers recommend close monitoring throughout pregnancy and continued health surveillance for children of mothers with HS to help manage these elevated risks. Recognizing HS as not only a dermatologic concern but also as a factor influencing broader health outcomes may lead to improved care strategies for affected families.