Elevated Depression Rates in Women with Gynecological Disorders: Implications for Care

A large register-based analysis demonstrates that women with reproductive health conditions have substantially higher rates of depression.

The registry analysis found a 44% higher prevalence of depression among women with common gynecologic disorders, including endometriosis, polycystic ovary syndrome (PCOS), and menstrual irregularities, compared with peers without these diagnoses.

Risk of depression peaked in the year after diagnosis and exceeded a twofold increase for endometriosis and painful menstrual disorders.

Diagnostic delay prolongs exposure to symptoms and psychosocial burden, with uncertainty and functional impairment often persisting for years before diagnosis. That delay represents a missed opportunity for earlier mental-health screening.