Analysis: Strontium Cream Reduces Pruritus in Hidradenitis Suppurativa Patients

Topical strontium cream significantly alleviates pruritus in patients with hidradenitis suppurativa (HS), according to a recent study published in the Journal of Clinical and Aesthetic Dermatology. 

The open-label study included 42 patients diagnosed with HS who experienced pruritus. Participants applied strontium cream to the affected areas twice daily for 2 weeks. The primary endpoint was the change in pruritus severity, assessed using a validated itch scale. Secondary measures included patient-reported satisfaction with the treatment and adverse event monitoring.

Results showed a substantial reduction in itch scores, with many participants reporting noticeable improvement within the first week. By the end of the study, 85% of patients reported a significant decrease in pruritus severity. Importantly, the treatment was well-tolerated, and no severe adverse events were documented. Mild skin irritation was observed in a small subset of patients but did not necessitate discontinuation.

Hidradenitis suppurativa is a chronic inflammatory skin condition characterized by painful nodules and abscesses, often accompanied by debilitating itch. Despite advancements in treatment for HS lesions, managing pruritus remains a clinical challenge. Strontium cream’s mechanism of action involves reducing inflammation and nerve irritation, making it a promising option for addressing this unmet need.

"Our findings indicate that strontium cream, when used as part of a real-world treatment regimen, significantly reduces pruritus," the authors wrote. "Furthermore, the inclusion of aluminum acetate in the studied cream may enhance its therapeutic effects. Known for its astringent and soothing properties, aluminum acetate may complement strontium by reducing inflammation and providing relief from itching."

The researchers emphasized the need for further randomized controlled trials to validate these findings and explore long-term safety and efficacy. Nevertheless, the study highlights strontium cream’s potential as a low-risk, accessible therapeutic option for HS-related pruritus.

Source: Walker R, et al. Journal of Clinical and Aesthetic Dermatology. 2025;18(3):12–14.