This CME webinar with live Q&A will provide an in-depth analysis of biomarker-driven strategies for the first-line treatment of metastatic gastric and gastroesophageal junction (GEJ) adenocarcinoma. Participants will learn to assess current and emerging biomarkers, analyze recent clinical trial data, and select optimal treatment regimens tailored to patient-specific characteristics. Additionally, the webinar will cover evidence-based approaches to monitor and manage adverse effects with the goal of improving treatment adherence and patient outcomes. This activity is designed to enhance the clinical decision-making process for healthcare professionals treating advanced gastric/GEJ cancers.