Malaria Vaccine Candidate Appears Safe & Produces Promising Immune Response in a Cohort of Tanzanian Infants
https://reachmd.com/news/malaria-vaccine-candidate-appears-safe-produces-promising-immune-response-in-a-cohort-of-tanzanian-infants/2452163/
An experimental malaria vaccine appears safe and promotes an immune response in African infants, one of the groups most vulnerable to severe malaria disease. There is currently only one malaria vaccine, "RTS,S" that is approved by the World Health Organization and offers partial disease protection.…
Transplant Recipients Experience Limited Protection With Primary COVID-19 Vaccination Series, but Third Dose Boosts Response
https://reachmd.com/news/transplant-recipients-experience-limited-protection-with-primary-covid-19-vaccination-series-but-third-dose-boosts-response/2452138/
BOSTON – Transplant recipients must take life-long immunosuppressive medications to prevent rejection, but these drugs can compromise the effectiveness of vaccines. New research indicates that lung and heart transplant recipients experienced diminished and delayed antibody responses to the first tw…
Implementing the Energy Transition
https://reachmd.com/news/implementing-the-energy-transition/2452145/
image: Co…
SARS-CoV-2 Induces Mitochondrial Dysfunction in Multiple Organs
https://reachmd.com/news/sars-cov-2-induces-mitochondrial-dysfunction-in-multiple-organs/2452142/
Since the beginning of the COVID-19 pandemic caused by the SARS-CoV-2 virus, researchers have been trying to determine why this virus creates such negative long-term effects compared with most coronaviruses. Now, a multi-institutional consortium of researchers led by a team at Child…
Long-term Use of Certain Reflux Medications is Associated with a Higher Risk of Dementia, Study Suggests
https://reachmd.com/news/long-term-use-of-certain-reflux-medications-is-associated-with-a-higher-risk-of-dementia-study-suggests/2452135/
CNN — Millions of Americans take medications known as proton pump inhibitors every day to treat heartburn and acid reflux, and in recent years, these drugs, also known as PPIs, have been linked to a greater risk of kidney failure, st…
Angina Drug Ranolazine Improves the Efficacy of Current Treatments for Melanoma in Mouse Models - Practical Dermatology
https://reachmd.com/news/angina-drug-ranolazine-improves-the-efficacy-of-current-treatments-for-melanoma-in-mouse-models-practical-dermatology/2452132/
August 10, 2023 The development of future clinical trials to validate and confirm the action of ranolazine in cancer patients will be facilitated by the fact that it has already been approved for use in humans and is being administered in clinical practice to treat chronic…
Modulating Type 1 Interferon May Expand Treatment Options for COVID-19
https://reachmd.com/news/modulating-type-1-interferon-may-expand-treatment-options-for-covid-19/2452126/
Mx1 is more highly localized to viral foci in untreated SARS-CoV-2-infected RMs and IFNmod treatment decreases lung pathology. Representative staining for (a) Mx1 and SARS-CoV-2 vRNA in lungs of untreated and IFNmod-treated RM…
Molnupiravir Administered at Human Effect Size-Equivalent Dose Found to Block SARS-CoV-2 Transmission in Ferrets
https://reachmd.com/news/molnupiravir-administered-at-human-effect-size-equivalent-dose-found-to-block-sars-cov-2-transmission-in-ferrets/2452131/
In vitro antiviral activity of nirmatrelvir. a Structure of nirmatrelvir. b Nirmatrelvir dose-response assays against SARS-CoV-2 WA1, and lineages B.1.1.7 (VOC α), B.1.351 (VOC β), P.1 (VOC γ), B.1.617.2 (VOC δ), B.1.1.529, BA…
New Machine-Learning Method May Aid Personalized Cancer Therapy
https://reachmd.com/news/new-machine-learning-method-may-aid-personalized-cancer-therapy/2452117/
Experimental procedure. The procedure includes presentation training, immunogenicity transfer learning and independent evaluation on multiple datasets. The circles labeled ‘Con’ indicate dataset concatenation. Input and databa…
Treatments for Poxviruses—Including Those Causing Mpox & Smallpox—May Already Exist in Licensed Drugs
https://reachmd.com/news/treatments-for-poxvirusesincluding-those-causing-mpox-smallpoxmay-already-exist-in-licensed-drugs/2452115/
Colorized transmission electron micrograph of monkeypox virus particles (red) cultivated and purified from cell culture. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID …