Human papillomavirus (HPV) is a common sexually transmitted infection spread through intimate skin-to-skin contact. Recommendations for the prevention of HPV have been updated since the initial HPV vaccine was first licensed in the US in 2006. Although immunization is routinely recommended in early adolescence, it is now also available for adults age 27-45 years, and certain patients may benefit from receiving it. However, there are limited resources available to help discuss HPV vaccination with adult patients. This activity is based on the latest CDC recommendations for vaccinating US adults against HPV and includes practical implementation strategies for shared clinical decision-making.