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Evolving Insights in Blood-Based Liquid Biopsies for Prostate Cancer Interrogation

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12/13/2023
eurekalert.org

BUFFALO, NY- December 8, 2023 – A new research perspective was published in Oncoscience (Volume 10) on November 30, 2023, entitled, “Evolving insights in blood-based liquid biopsies for prostate cancer interrogation.”

During the last decade, blood sampling of cancer patients aimed at analyzing the presence of cells, membrane-bound vesicles, or molecules released by primary tumors or metastatic growths emerged as an alternative to traditional tissue biopsies. The advent of this minimally invasive approach, known as blood-based liquid biopsy, began to play a pivotal role in the management of diverse cancers, establishing itself as a vital component of precision medicine.

In this new paper, researchers R. Daniel Bonfil and Ghaith Al-Eyd from Nova Southeastern University discuss three blood-based liquid biopsies, namely circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and tumor-derived exosomes, as they relate to prostate cancer (PCa) management. 

“In this research perspective, we present a comprehensive overview of the recent advances related to the clinical significance of blood-based liquid biopsies in PCa, with a primary emphasis placed on key biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and exosomes.”

The advances achieved in the molecular characterization of these types of liquid biopsies and their potential to predict recurrence, improve responses to certain treatments, and evaluate prognosis, in PCa patients, are highlighted herein. While there is currently full clinical validation for only one CTC-based and one ctDNA-based liquid biopsy for patients with metastatic castration-resistant PCa, the adoption of additional methods is anticipated as they undergo standardization and achieve analytical and clinical validation. Advantages and disadvantages of different blood-based liquid biopsy approaches in the context of PCa are outlined in this paper, while also considering potential synergies through combinatory strategies.

“We anticipate that, with the assistance of artificial intelligence based on pre-established parameters, the utilization of blood-based liquid biopsies will soon enhance the stratification of PCa patients and facilitate timely therapeutic decision making.”

Read the full paper: DOI:https://doi.org/10.18632/oncoscience.592

Correspondence to: R. Daniel Bonfil

Email: rbonfil@nova.edu

Keywords: prostate cancer, liquid biopsy, circulating tumor cells (CTC), circulating tumor DNA (ctDNA), exosomes

AboutOncoscience

Oncoscience is a peer-reviewed, open-access, traditional journal covering the rapidly growing field of cancer research, especially emergent topics not currently covered by other journals. This journal has a special mission: Freeing oncology from publication cost. It is free for the readers and the authors.

To learn more about Oncoscience, visit Oncoscience.us and connect with us on social media:

For media inquiries, please contact media@impactjournals.com.

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Method of Research

Commentary/editorial

Subject of Research

People

Article Title

Evolving insights in blood-based liquid biopsies for prostate cancer interrogation

Article Publication Date

30-Nov-2023

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Schedule25 May 2024