Global Breast Cancer ADC Learning Hub

Advancing the Evidence-Based Use of Antibody-Drug Conjugates Across the Breast Cancer Care Continuum

Antibody-drug conjugates are transforming the treatment of breast cancer across molecular subtypes, disease stages, and lines of therapy.

The Global Breast Cancer ADC Learning Hub provides oncology clinicians with timely, evidence-based education addressing HER2-directed and TROP2-directed ADCs, including emerging clinical trial data, treatment selection, sequencing, safety management, and practical application across diverse global practice settings.

This independent medical education initiative is designed for oncology clinicians and supported through educational grants from Daiichi Sankyo.

A woman in a patterned headscarf looking towards a sunrise, with an antibody-drug conjugate binding a tumour cell rendered alongside her.

The Expanding Role of ADCs in Breast Cancer

Explore the scientific advances, clinical evidence, and practice challenges shaping the use of antibody-drug conjugates worldwide.

HER2-Directed ADCs

Explore advances in the use of HER2-directed ADCs across HER2-positive, HER2-low, and HER2-ultralow breast cancer.

Key Areas:

  • Early breast cancer
  • Metastatic breast cancer
  • Treatment sequencing
  • CNS metastases
  • Biomarker interpretation
  • Resistance and disease progression
  • Adverse event monitoring and management

TROP2-Directed ADCs

Examine emerging evidence for TROP2-directed ADCs in triple-negative and hormone receptor-positive breast cancer.

Key Areas:

  • First-line metastatic TNBC
  • Immunotherapy-ineligible patients
  • Later-line metastatic disease
  • Early-stage TNBC
  • Treatment selection and sequencing
  • Differentiated safety profiles
  • Proactive toxicity management

Breast Cancer and ADC Practice Insights

Key data highlighting the global disease burden, evolving treatment landscape, and educational needs surrounding ADC-based therapy.

2.4 Million

An estimated 2.4 million women were diagnosed with breast cancer worldwide in 2024. Breast cancer remains the most commonly diagnosed cancer among women, and the most common cause of cancer death in women.

World Health Organization. (2026, July 3). Breast cancer. World Health Organization

694,000

Breast cancer caused an estimated 694,000 deaths globally in 2024.

World Health Organization. (2026, July 3). Breast cancer. World Health Organization

1 in 20

Approximately 1 in 20 women worldwide will be diagnosed with breast cancer during their lifetime.

International Agency for Research on Cancer. (2025, February 24). Breast cancer cases and deaths are projected to rise globally. IARC

Expert Faculty

The Global Breast Cancer ADC Learning Hub is guided by internationally recognized breast cancer experts who provide scientific oversight, regional perspectives, and practical guidance on the clinical use of ADCs.

Resources

Advocacy Groups