Cardio-Kidney-Metabolic
Health Learning Center
Advancing care across patients with heart failure, chronic kidney disease and diabetes.
Your Comprehensive Hub for Excellence in Heart Failure, Chronic Kidney Disease and Diabetes
Through expert interviews, case discussions, expert panels, and patient perspectives, renowned global experts share the latest evidence-based guidance and real-world insights for practicing clinicians. This learning center features education spanning heart failure, chronic kidney disease with type 2 diabetes, chronic kidney disease with type 1 diabetes, and non-diabetic chronic kidney disease.
Join our growing community of cardiology, nephrology, endocrinology, and primary care clinicians by engaging with this educational content and sharing it with your colleagues and care teams.
Together, we can advance the future of Cardio-Kidney-Metabolic care worldwide!
~ 50 %
of patients with chronic kidney disease (CKD) stages 4 to 5 also have CVD1
~ 40 %
of individuals with diabetes develop diabetic kidney disease2
~ 25 %
prevalence of concurrent comorbidities associated with CKM worldwide3
Educational Programs
Resource Center
Discover a curated collection of foundational, practical, and real-world educational resources at your fingertips. Click on a link to get started.
Agarwal R, Green JB, Heerspink HJL, Mann JFE, McGill JB, Mottl AK, Rosenstock J, Rossing P, Vaduganathan M, Brinker M, Edfors R, Li N, Scheerer MF, Scott C, Nangaku M; CONFIDENCE Investigators. Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes. N Engl J Med. 2025 Jun 5. doi: 10.1056/NEJMoa2410659. Epub ahead of print. PMID: 40470996.
Taub PR, Greene SJ, Fudim M. The role of finerenone in the concomitant management of chronic kidney disease-type 2 diabetes and the implication for heart failure prevention and treatment. Heart Fail Rev. 2025 May 31. doi: 10.1007/s10741-025-10520-3. Epub ahead of print. PMID: 40448875.
Butt JH, Jhund PS, Henderson AD, et al. Finerenone According to Frailty in Heart Failure: A Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. Published online June 18, 2025. doi:10.1001/jamacardio.2025.1775
Maria A. Pabon, Gerasimos Filippatos, Brian L. Claggett, Michael Zi Miao, Akshay S. Desai, Pardeep S. Jhund, Alasdair Henderson, Meike Brinker, Patrick Schloemer, Lucas Hofmeister, Li Li, Carolyn S.P. Lam, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Peter Rossing, Luis M. Ruilope, Stefan D. Anker, Bertram Pitt, Rajiv Agarwal, John J.V. McMurray, Scott D. Solomon, Muthiah Vaduganathan, Finerenone Reduces New-Onset Atrial Fibrillation across the Spectrum of Cardio-Kidney-Metabolism: the FINE-HEART Pooled Analysis, JACC. 2025, ISSN 0735-1097, https://doi.org/10.1016/j.jacc.2025.03.429.
Matsumoto S, Henderson AD, Jhund PS, et al. Finerenone and Atrial Fibrillation in Heart Failure: A Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. Published online March 29, 2025. doi:10.1001/jamacardio.2025.0848
Ostrominski, J, Claggett, B, Causland, F. et al. EFFICACY AND SAFETY OF FINERENONE ACROSS THE SPECTRUM OF KIDNEY RISK IN HEART FAILURE WITH MILDLY REDUCED OR PRESERVED EJECTION FRACTION. JACC. 2025 Apr, 85 (12_Supplement) 1167.https://doi.org/10.1016/S0735-1097(25)01651-1
Cunningham, J, Claggett, B, Vaduganathan, M. et al. EFFECT OF FINERENONE ON N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE IN HEART FAILURE WITH MILDLY REDUCED OR PRESERVED EJECTION FRACTION: THE FINEARTS-HF TRIAL. JACC. 2025 Apr, 85 (12_Supplement) 1203.
Desai AS, Jhund PS, Vaduganathan M, et al. Mode of Death in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. Published online March 30, 2025. doi:10.1001/jamacardio.2025.0860
Butt JH, Henderson AD, Jhund PS, et al. Finerenone, obesity, and heart failure with mildly reduced/preserved ejection fraction: prespecified analysis of FINEARTS-HF. J Am Coll Cardiol. 2025;85(2):140-155. doi:10.1016/j.jacc.2024.10.111
Mentz RJ, Anker SD, Pitt B, et al; on behalf of the FIDELIO‐DKD and FIGARO‐DKD Investigators. Efficacy and safety of finerenone in patients with chronic kidney disease and type 2 diabetes by diuretic use: a FIDELITY analysis. Eur J Heart Fail. Published online January 17, 2025. doi:10.1002/ejhf.3569
Mc Causland FR, Vaduganathan M, Claggett BL, et al. Finerenone and kidney outcomes in patients with heart failure: the FINEARTS-HF trial. J Am Coll Cardiol. 2025;85(2):159-168. doi:10.1016/j.jacc.2024.10.091
Solomon SD, McMurray JJV, Vaduganathan M, et al; FINEARTS-HF Committees and Investigators. Finerenone in heart failure with mildly reduced or preserved ejection fraction. N Engl J Med. 2024;391(16):1475-1485. doi:10.1056/NEJMoa2407107
Agarwal R, Filippatos G, Pitt B, et al; FIDELIO-DKD and FIGARO-DKD investigators. Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis. Eur Heart J. 2022;43(6):474-484. doi:10.1093/eurheartj/ehab777
Agarwal R, Kolkhof P, Bakris G, et al. Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine. Eur Heart J. 2021;42(2):152-161. doi:10.1093/eurheartj/ehaa736
Our Faculty
From academia to private practice, leading experts have joined together to advance the standard of CKM care worldwide:
Carolyn S. P. Lam, MBBS, PhD, MRCP, MS, FACC, FAMS, FESC
Jürgen Floege, MD
Muthiah Vaduganathan, MD, MPH
Scott Solomon, MD
Mikhail Kosiborod, MD
Pardeep Jhund, MD, PhD
Hiddo L. Heerspink, PhD
John McMurray, MD
Akshay S. Desai, MD
Csaba P. Kovesdy, MD
Finnian R. Mc Causland, MD
Orly Vardeny, MD
References:
1. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050686
2. https://www.ncbi.nlm.nih.gov/books/NBK571718/
3. https://www.sciencedirect.com/science/article/abs/pii/S0033062024001488
