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Medical Industry Feature: Trends, Treatments, & Tips for the Flu Season

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Trends, Treatments, & Tips for the Flu Season

Trends, Treatments, & Tips for the Flu Season
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How can you prevent and treat the flu in your patients? These tips can help.

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  • Overview

    Due to the high prevelance of influenza each winter, knowing how to treat those most at risk is essential. That's why Dr. Frank LoVecchio and Dr. Casey Lafferty are here to discuss the 2019-2020 flu season activity and patterns, along with preventive tips and treatment options you can provide to your patients. 

  • Indication

    XOFLUZA™ is indicated for the treatment of acute uncomplicated influenza in patients 12 years of age and older who have been symptomatic for no more than 48 hours and who are:

    • otherwise healthy, or
    • at high risk of developing influenza-related complications

    Limitations of Use
    Influenza viruses change over time, and factors such as the virus type or subtype, emergence of resistance, or changes in viral virulence could diminish the clinical benefit of antiviral drugs. Consider available information on drug susceptibility patterns for circulating influenza virus strains when deciding whether to use XOFLUZA.

  • Contraindications

    XOFLUZA is contraindicated in patients with a history of hypersensitivity to baloxavir marboxil or any of its ingredients. Serious allergic reactions have included anaphylaxis, angioedema, urticaria, and erythema multiforme.

  • Important Safety Information (ISI)

    Hypersensitivity
    Cases of anaphylaxis, urticaria, angioedema, and erythema multiforme have been reported in postmarketing experience with XOFLUZA.  Appropriate treatment should be instituted if an allergic-like reaction occurs or is suspected. The use of XOFLUZA is contraindicated in patients with known hypersensitivity to XOFLUZA.

    Bacterial Infections
    There is no evidence of the efficacy of XOFLUZA in any illness caused by pathogens other than influenza viruses. Serious bacterial infections may begin with influenza-like symptoms or may coexist with, or occur as, a complication of influenza. XOFLUZA has not been shown to prevent such complications. Prescribers should be alert to potential secondary bacterial infections and treat them as appropriate.

    Drug Interactions
    Co-administration with polyvalent cation-containing products may decrease plasma concentrations of baloxavir, which may reduce XOFLUZA efficacy. Avoid co-administration of XOFLUZA with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives or antacids, or oral supplements (eg, calcium, iron, magnesium, selenium, or zinc).

    Concurrent Use with Live Attenuated Influenza Vaccine
    The concurrent use of XOFLUZA with intranasal live attenuated influenza vaccine (LAIV) has not been evaluated. Concurrent administration of antiviral drugs may inhibit viral replication of LAIV and thereby decrease the effectiveness of LAIV vaccination. Interactions between inactivated influenza vaccines and XOFLUZA have not been evaluated.

    Most Common Adverse Reactions
    Adverse events (regardless of causality assessment) reported in at least 1% of adult and adolescent subjects (n=1,440) who received XOFLUZA at the recommended dose included diarrhea (3%), bronchitis (3%), nausea (2%), sinusitis (2%), and headache (1%).

    For additional important safety information, please see XOFLUZA full Prescribing Information at www.XOFLUZA.com.

    You are encouraged to report side effects to Genentech by calling 1-888-835-2555 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

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