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Treating Psoriatic Arthritis (PsA) and Ankylosing Spondylitis (AS): A Virtual Simulation



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Explore data on a treatment option for psoriatic arthritis (PsA) and ankylosing spondylitis (AS) through the lens of hypothetical patient cases.

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Important Safety Information

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  • Overview

    Meet our hypothetical patients, Mark and Melanie. Mark has active PsA, and Melanie has active AS. Learn more about their disease histories, current symptoms, and goals in addition to data on the treatment option COSENTYX® (secukinumab) in this virtual patient simulation guided by Dr Evan Siegel and Dr Reeti Joshi. Dr Siegel is a rheumatologist at Arthritis and Rheumatism Associates in Rockville, Maryland, and Dr Joshi is a rheumatologist with Advanced Rheumatology Associates in Beaumont, Texas.

    Physicians were compensated for their time. Simulation developed by Novartis Pharmaceuticals Corporation.


    COSENTYX® (secukinumab) is indicated for the treatment of moderate to severe plaque psoriasis in patients 6 years and older who are candidates for systemic therapy or phototherapy.

    COSENTYX is indicated for the treatment of active psoriatic arthritis (PsA) in patients 2 years of age and older.

    COSENTYX is indicated for the treatment of adult patients with active ankylosing spondylitis (AS).

    COSENTYX is indicated for the treatment of adult patients with active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation.

    COSENTYX is indicated for the treatment of active enthesitis-related arthritis (ERA) in patients 4 years of age and older.


    COSENTYX is contraindicated in patients with a previous serious hypersensitivity reaction to secukinumab or to any of the excipients in COSENTYX. Cases of anaphylaxis have been reported during treatment with COSENTYX.


    COSENTYX may increase the risk of infections. In clinical trials, a higher rate of infections was observed in COSENTYX treated subjects compared to placebo-treated subjects. In placebo-controlled clinical trials in subjects with moderate to severe plaque psoriasis, higher rates of common infections, such as nasopharyngitis (11.4% versus 8.6%), upper respiratory tract infection (2.5% versus 0.7%) and mucocutaneous infections with candida (1.2% versus 0.3%) were observed with COSENTYX compared with placebo. A similar increase in risk of infection was seen in placebo-controlled trials in subjects with psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondyloarthritis. The incidence of some types of infections appeared to be dose-dependent in clinical studies. In the postmarketing setting, serious and some fatal infections have been reported in patients receiving COSENTYX.

    Exercise caution when considering the use of COSENTYX in patients with a chronic infection or a history of recurrent infection.

    Instruct patients to seek medical advice if signs or symptoms suggestive of an infection occur. If a patient develops a serious infection, monitor the patient closely and discontinue COSENTYX until the infection resolves.

    Pre-treatment Evaluation for Tuberculosis
    Evaluate patients for tuberculosis (TB) infection prior to initiating treatment with COSENTYX. Avoid administration of COSENTYX to patients with active TB infection. Initiate treatment of latent TB prior to administering COSENTYX. Consider anti-TB therapy prior to initiation of COSENTYX in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Monitor patients closely for signs and symptoms of active TB during and after treatment.

    Inflammatory Bowel Disease
    Caution should be used when prescribing COSENTYX to patients with inflammatory bowel disease. Exacerbations, in some cases serious, occurred in COSENTYX treated subjects during clinical trials in plaque psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondyloarthritis. In addition, new onset inflammatory bowel disease cases occurred in clinical trials with COSENTYX. In an exploratory trial in 59 subjects with active Crohn’s disease, there were trends toward greater disease activity and increased adverse events in the secukinumab group as compared to the placebo group. Patients who are treated with COSENTYX should be monitored for signs and symptoms of inflammatory bowel disease.

    Eczematous Eruptions
    In postmarketing reports, cases of severe eczematous eruptions, including atopic dermatitis-like eruptions, dyshidrotic eczema, and erythroderma, were reported in patients receiving COSENTYX; some cases resulted in hospitalization. The onset of eczematous eruptions was variable, ranging from days to months after the first dose of COSENTYX.

    Treatment may need to be discontinued to resolve the eczematous eruption. Some patients were successfully treated for eczematous eruptions while continuing COSENTYX.

    Hypersensitivity Reactions
    Anaphylaxis and cases of urticaria occurred in COSENTYX treated subjects in clinical trials. If an anaphylactic or other serious allergic reaction occurs, administration of COSENTYX should be discontinued immediately and appropriate therapy initiated.

    The removable caps of the COSENTYX Sensoready® pen and the COSENTYX 1 mL and 0.5 mL prefilled syringes contain natural rubber latex, which may cause an allergic reaction in latex-sensitive individuals. The safe use of the COSENTYX Sensoready pen or prefilled syringe in latex-sensitive individuals has not been studied.

    Prior to initiating therapy with COSENTYX, consider completion of all age appropriate immunizations according to current immunization guidelines. COSENTYX may alter a patient’s immune response to live vaccines. Avoid use of live vaccines in patients treated with COSENTYX.

    Most common adverse reactions (>1%) are nasopharyngitis, diarrhea, and upper respiratory tract infection

    Please see full Prescribing Information, including Medication Guide.

    Sponsored by Novartis Pharmaceuticals Corporation

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Schedule11 Dec 2023