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This medical industry feature, titled “Rosacea's Impact is More than Skin Deep...Shifting Treatment Paradigms” is provided in partnership with Galderma Laboratories, L.P.
Dr. Hilary Baldwin is a paid consultant for Galderma Laboratories, L.P.
Here's your guest Dr. Hilary Baldwin.
For the 16 million Americans living with rosacea1, coping with the visible symptoms - like redness and acne-like breakouts - can be a constant battle. But the burden of this common skin disease goes far beyond what we see on the surface2.
In fact, over 30 percent of patients with rosacea are more likely to suffer from non-visible symptoms, such as stinging, burning, itching, and pain2. And when combined with issues seen on the skin’s surface, the physical and psychological tolls on patient quality of life become profound.
In a survey of over 16 hundred rosacea patients, 88 percent reported experiencing feelings of embarrassment from their condition, 54 percent experienced anxiety and helplessness, and 43 percent experienced depression.
But these debilitating impacts are a direct result of symptom severity, and there are hopeful signs for patients who achieve symptom control. A global survey of 710 patients found that 49 percent of respondents who achieved clear skin believed that rosacea had no impact on their quality of life3.
This is why it’s so important for clinicians to take advantage of the available treatment options to help patients with their rosacea. One such option is SOOLANTRA® (ivermectin) Cream, 1%.
SOOLANTRA Cream is a once-daily cream indicated for the treatment of inflammatory lesions4 of rosacea. It's a highly tolerable treatment among patients. In clinical trials with SOOLANTRA Cream, the most common adverse reactions (incidence ≤1%) included skin burning sensation and skin irritation.
The ivermectin molecule has a proposed dual mechanism of action consisting of both anti-parasitic and anti-inflammatory activities. Ivermectin decreases cellular and humoral immune responses by altering neutrophil and phagocyte activity6,7. This anti-inflammatory response is believed to come from significant downregulation of pro-inflammatory mediators, including IL-6, IL-8, LL-37, HBD3, KLK-5, and TNF-a8,9,10,11,12.
Based on clinical study results, beginning and continuing treatment with SOOLANTRA Cream improves the opportunity of achieving clearer skin,13 an essential factor in benefiting our patients’ quality of life.
Indication: SOOLANTRA® (ivermectin) Cream, 1% is indicated for the treatment of inflammatory lesions of rosacea. Not for oral, ophthalmic or intravaginal use. Adverse Events: In clinical trials with SOOLANTRA Cream, the most common adverse reactions (incidence less than or equal to 1%) included skin burning sensation and skin irritation.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
WWW.FDA.GOV/MEDWATCH or call 1-800-FDA-1088.
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- American Academy of Dermatology. https://www.aad.org/media/stats/conditions/skin-conditions-by-the-numbers.
- Rosacea: Beyond the visible report. Available at: https://hosted.bmj.com/rosaceabeyondthevisible. Accessed February 2019. Huynh T. Burden of Disease: The Psychosocial Impact of Rosacea on a Patient's Quality of Life. Am Health Drug Benefits. 2013; 6:348-354.
- Tan J, et al. Rosacea. Beyond the visible. 2018. Available at https://hosted.bmj.com/rosaceabeyondthevisible. Accessed October 15, 2018.
- SOOLANTRA (ivermectin) cream: Highlights of prescribing information. Issued: July 2018. Available at https://www.galderma.com/us/sites/g/files/jcdfhc341/files/2019-01/Soolantra_Cream_PI.pdf. Accessed: May 2019.
- Stein Gold L, et al. Efficacy and Safety of lvermectin 1% Cream in Treatment of Papulopustular Rosacea: Results of Two Random¬ ized, Double-Blind, Vehicle-Control led Pivotal Studies. J Drugs Dermatol. 2014;7 3:316-323.
- Ci X, et al. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fundam Clin Pharmacol. 2009;23:449-455.
- Dourmishev AL, et al. Ivermectin: pharmacology and application in dermatology. Int J Dermatol. 2005;44:981-988.
- Schaller M, et al. Dual anti-inflammatory and anti-parasitic action of topical ivermectin 1% in papulopustular rosacea. J Eur Acad Dermatol Venereal. 2017;31:7907-1911.
- Ebbelaar CCF, et al. Topical lvermectin in the Treatment of Papulopustular Rosacea: A Systematic Review of Evidence and Clinical Guideline Recommendations. Dermatol Ther. 2018;8:379-387.
- Xinxin C, et al. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-Band mitogen-activated protein kinase activation pathway. Fundamental & Clinical Pharmacology. 2009;23:449-455.
- Menonville ST, et al. Topical Treatment of Rosacea with lvermectin Inhibits Gene Expression of Cathe1icidin Innate Im mune· Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin Models. Dermatol Ther (Heidelb). 2017;7:213-225.
- Del Rosso JQ, et al. Why is rosacea considered to.be an inflammatory disorder? The primary role, clinical relevance, and therapeutic correlations of abnormal innate immune response in rosacea-proneskin. J Drugs Dermatol. 2012;17 :694-700.
- Dall’Oglio F, et al. Clinical and erythema-directed imaging evaluation of papulo-pustular rosacea with ivermectin: a 32 weeks duration study. J Derm Treat. 2019: https://doi.org/10/1080/09546634.2019.1572860.