Potential Mechanisms of Chronic Cough

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Potential Mechanisms of Chronic Cough

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    Chronic cough is a heterogenous condition with various potential underlying mechanisms.Here’s a look at some potential mechanisms.

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    • Overview

      Cough is a fundamental protective reflex to airway irritation, but it can become disordered and lead to a persistent symptom complex.2,3 This video reviews 2 afferent neuronal pathways which may be involved in the regulation of cough,4,5 including some potential mechanisms for chronic cough (defined as a cough lasting > 8 weeks).6

      References: 1. Mazzone SB, et al. Lancet Respir Med. 2018;6:636-646. 2. Keller JA, et al. CHEST. 2017;152:833-841. 3. Gibson PG. J Allergy Clin Immunol Pract. 2019;7:1724-1729. 4. Canning BJ. Pulm Pharmacol Ther. 2011:24:295-299. 5. Mazzone SB, Undem BJ. Physiol Rev. 2016;96:975-1024. 6. Irwin RS, et al. Chest. 2018;153:196-209.

      Copyright © 2021 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved.
      US-OGM-00553 07/21

    Schedule28 Jun 2022
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