Transcript
Announcer:
Welcome to ReachMD. This medical industry feature titled "Chronic Pancreatitis & EPI: A Patient Case Study" is sponsored by AbbVie US Medical Affairs.
The US Medical Affairs department of AbbVie Incorporated is the sole author and copyright owner of this presentation and has paid ReachMD to host this presentation. AbbVie is solely responsible for all written content within this presentation. Copyright 2023 AbbVie Incorporated. All rights reserved.
Personal opinions and thoughts are Dr. Jodie Barkin’s own. Dr. Barkin serves as a paid consultant for AbbVie.
Dr. Barkin:
Hello. I’m Dr. Jodie Barkin-Associate Professor of Clinical Medicine at the University of Miami in Miami Florida and Associate Medical Director of the University of Miami Pancreas Center.
Today I am going to discuss with you the case of a 63-year-old man with a history of recurrent acute pancreatitis secondary to alcohol, with chronic alcohol and smoking intake.
The patient presented to our clinic with chronic, dull epigastric pain, which intensified post-prandially. He also experienced bloating and unintentional weight loss. And in addition, he notes changes in the frequency and the consistency of his bowel movements.
Laboratory tests showed that he had vitamin D deficiency, as well as low fecal elastase at 34 μg/g, consistent with exocrine pancreatic insufficiency, often referred to as EPI.
The CT scan showed chronic pancreatitis changes noted by parenchymal calcifications, parenchymal atrophy and pancreatic ductal dilatation. You make a diagnosis of chronic pancreatitis with exocrine insufficiency.
The patient is then started on pancreatic Enzyme Replacement Therapy, or PERT and vitamin D replacement. He remains in an active imaging screening program for pancreatic cancer and is following with endocrinology for the management of his concomitant diabetes.
So, let’s review the etiology and risk factors for EPI in patients with Chronic Pancreatitis.
Chronic pancreatitis is an inflammatory syndrome involving recurrent or sustained injury to the pancreas.1
The exocrine pancreas is responsible for the production of digestive enzymes including lipases, amylases, and proteases, as well as bicarbonate secretion.2
And the pancreas on average produces about 720k units of lipase per meal.3
Chronic pancreatitis is caused by hereditary and environmental factors.4
Chronic ongoing inflammation or recurrent inflammatory episodes may eventually lead to fibrosis of the gland.1
Acinar cells are responsible for the production of digestive enzymes and are destroyed as a result of this immune mediated cascade.1
This sustained pancreatic injury, in combination with potential pancreatic ductal obstruction and decreased bicarbonate production, reduces the production and delivery of digestive enzymes, making chronic pancreatitis a major cause of exocrine pancreatic insufficiency.5
Fat malabsorption typically manifests after a patient loses 90% of their exocrine function.5
And EPI leads to diarrhea, steatorrhea, maldigestion of food, and associated symptoms such as weight loss, and fat-soluble vitamin deficiencies.1
The pooled prevalence of Chronic Pancreatitis is estimated to be 36.9-41.8 per 100,000 persons.6
Men and women experience varied susceptibility to these risk factors, with most cases of chronic pancreatitis in men being alcohol related, whereas most cases of chronic pancreatitis in women are found to be idiopathic.7
The prevalence of EPI increases with the duration of disease of Chronic Pancreatitis, starting first at 6-22% at the time of diagnosis, and increasing over time to 28% after 5 years post diagnosis. And then rising to 50% in patients that are approximately 12 years post chronic pancreatitis diagnosis.
And therefore, the probability of developing EPI increases with disease duration of Chronic Pancreatitis.8,9
American College of Gastroenterology Clinical Guide: Chronic Pancreatitis
EPI should be suspected in those with the following:
- Long-standing chronic pancreatitis
- Chronic pancreatitis with any of the following:
- Weight loss
- Malnutrition
- Diarrhea
- Steatorrhea
- Osteoporosis
- Osteopenia
And it’s therefore recommended to monitor your patients for the development of the signs and symptoms of EPI with screening for this condition at regular intervals with additional testing when indicated. Thank you so much for joining me today on this educational activity about exocrine pancreatic insufficiency or EPI in chronic pancreatitis.4
American College of Gastroenterology Clinical Guide: Chronic Pancreatitis
Clinical suspicion is often sufficient to make an EPI diagnosis without formal fecal fat measurement in the proper clinical context.
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References:
- Kleeff J, Whitcomb DC, Shimosegawa T, et al. Chronic pancreatitis. Nat Rev Dis Primers. 2017;3:17060. doi:10.1038/nrdp.2017.60
- Williams JA. Regulation of acinar cell function in the pancreas. Curr Opin Gastroenterol. 2010 Sep;26(5):478-83. doi: 10.1097/MOG.0b013e32833d11c6.
- Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54 Suppl 6(Suppl 6):vi1-vi28. doi:10.1136/gut.2005.065946
- Gardner TB, Adler DG, Forsmark CE, Sauer BG, Taylor JR, Whitcomb DC. ACG Clinical Guideline: Chronic Pancreatitis. Am J Gastroenterol. 2020;115(3):322-339. doi:10.14309/ajg.0000000000000535
- Jawaid S, Forsmark CE. Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: True Association or EPI phenomenon?. Dig Dis Sci. 2019;64(7):1731-1733. doi:10.1007/s10620-019-05653-z
- Conwell DL, Lee LS, Yadav D, et al. American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014;43(8):1143-1162. doi:10.1097/MPA.0000000000000237
- Romagnuolo J, Talluri J, Kennard E, et al. Clinical Profile, Etiology, and Treatment of Chronic Pancreatitis in North American Women: Analysis of a Large Multicenter Cohort. Pancreas. 2016;45(7):934-940. doi:10.1097/MPA.0000000000000616
- Layer P, Yamamoto H, Kalthoff L, Clain JE, Bakken LJ, DiMagno EP. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology. 1994;107(5):1481-1487. doi:10.1016/0016-5085(94)90553-3
- Sandhu BS, Hackworth WA, Stevens S, Bouhaidar DS, Zfass AM, Sanyal AJ. Recurrent flares of pancreatitis predict development of exocrine insufficiency in chronic pancreatitis. Clin Gastroenterol Hepatol. 2007;5(9):1085-1007. doi:10.1016/j.cgh.2007.04.01
VERSION 1.0 | FEBRUARY 2023 | ABBV-US-01115-MC
