Cancer mortality rates are declining almost uniformly in medicine today. One exception to this trend is melanoma: mortality rates for the disease appear to be holding steady. Owing perhaps to gender-based skin differences and lifestyle habits, men tend to be at higher risk for melanomas, and other skin disorders, including squamous cell carcinomas. Dr. Susan Swetter, associate professor of dermatology and director of the Pigmented Lesion and Cutaneous Melanoma Clinic at Stanford University Medical Center in Palo Alto, California, talks with host Dr. Jennifer Shu about the range of dermatologic issues that are more prevalent in men than women. Recognizing these risks, how can we improve our strategies for prevention and earlier detection of skin disease in men?